|ERIC R. KANDEL
Location: P.I. Annex-664
We combine behavioral, cellular, and molecular biological approaches to delineate the changes that underlie simple forms of learning and memory in invertebrates and vertebrates. In invertebrates the focus of our research is on the gill-withdrawal reflex of Aplysia. We study three elementary forms of learning: habituation, sensitization, and classical conditioning. Recently we have reconstituted critical components of this learning in dissociated cell culture, and we now use the reconstituted system to examine the molecular mechanisms which contribute to short- and long-term memory.
Goelet, P., Castellucci, V., Schacher, S. and Kandel, E.R. (1986) The long and short of long-term memory. Nature 322, 419-422.
Bartsch, D., Ghirardi, M., Skehel, P.A., Karl, K.A., Herder, S.P., Chen M., Bailey, C.H. and Kandel, E.R. (1995) Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change. Cell 83, 979- 992.
Martin, K.C., Casadio, A., Zhu, H., Yaping, E., Rose, J., Bailey, C.H., Chen, M., and Kandel, E.R. (1998) Synapse-specific transcription-dependent long-term facilitation of the sensory to motor neuron connection in Aplysia: A function for local protein synthesis in memory storage. Cell 91:927-938.
Casadio, A., Martin, D.C., Giuststto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C.H., and Kandel, E.R. (1999) A transient neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99:221-237.
Malleret, G., Haditsch, U., Genoux, D., Jones M.W., Bliss, T.V.P., Vanhoose, A.M., Weitlauf, C., Kandel, E.R., Winder, D.G. and Mansuy, I.M., (2001) Inducible and reversible enhancement of learning, memory and long-term potentiation by genetic inhibition of calcineurin. Cell 104:675-686.