faculty & research

Faculty

The name of each faculty member is linked to a more detailed description of that person's research interests

Faculty Member Affiliations Research Interests

Richard Axel

Axel, Richard

Email:ra27@cumc.columbia.edu
Phone: 212-305-6915
Fax:212-923-7249                  
Location:HHSC Rm.1014

University Professor, Biochemistry & Molecular Biophysics, Neuroscience, Pathology & Cell Biology
Investigator, Howard Hughes Medical Institute

Defining the logic of olfactory perception; how individual sensory neurons express a specific receptor and how the brain distinguishes which receptors have been activated

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Califano, Andrea

Email: califano@c2b2.columbia.edu
Phone:212-851-5183
Fax: 212-305-9500
Location: C2B2 Rm. 912    

Professor of Systems Biology in the Department of Biochemistry and Molecular Biophysics, in the Institute for Cancer Genetics, and in the Department of Biomedical Informatics. Director, Columbia Initiative in Systems Biology Director, JP Sulzberger MD Columbia Genome Center Associate Director, Herbert Irving Comprehensive Cancer Center

Dissecting and interrogating the regulatory logic of the cancer cell using a combination of high-throughput experimental and computational systems biology approaches. Identifying master regulators of stem cell pluripotency and lineage specific differentiation. 

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Fernandez, Israel

Email: isf2106@cumc.columbia.edu
Phone: 212-305-4011
Location: BB Rm. 507

Assistant Professor of Biochemistry and Molecular Biophysics

 

JOACHIM FRANK

Frank, Joachim

Email: jf2192@cumc.columbia.edu
Phone: 212-305-9510
Fax: 212-305-9500
Location: BB Rm. 221

Professor of Biochemistry & Molecular Biophysics and Biological Sciences
Investigator, Howard Hughes Medical Institute

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction. Using these methods, and flexible fitting of X-ray structures, the dynamics of the decoding and translocation mechanisms are revealed.

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STEPHEN P. GOFF

Goff, Stephen P.

Email: spg1@cumc.columbia.edu
Phone: 212-305-3794
Fax: 212-305-5106
Location: HHSC Rm. 1310

Higgins Professor of Biochemistry and Molecular Biophysics and Professor of Microbiology
Investigator, Howard Hughes Medical Institute

Retroviral replication; tyrosine kinase oncogenes

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MAX E. GOTTESMAN

Gottesman, Max E.

Email: meg8@cumc.columbia.edu
Phone: 212-305-6900
Fax: 212-305-1741
Location: HHSC Rm. 1504

Charles H. Revson Professor of Biochemistry and Molecular Biophysics and Microbiology (in the Institute of Cancer Research); Director - Institute Cancer Research

Regulation of transcription termination in /E. coli/ and bacteriophage; DNA damage repair and signal transduction in eukaryotes.

 

ERIC C. GREENE

Greene, Eric C.

Email: ecg2108@cumc.columbia.edu
Phone: 212-342-2944

Fax:  212-305-5427
Location: BB Rm. 536

Associate Professor Biochemistry & Molecular Biophysics
Investigator, Howard Hughes Medical Institute

 

Molecular mechanisms of DNA recombination and repair; single molecule fluorescence microscopy and other biochemical approaches.

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IVA GREENWALD

Greenwald, Iva

Email: iva.columbia@gmail.edu
Phone: 212-305-6928
Fax: 212-305-1721
Location: HHSC Rm. 720A

Professor of Biochemistry & Molecular Biophysics and Genetics & Development
Investigator, Howard Hughes Medical Institute

LIN-12/Notch signaling and cell-cell interactions during development.

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WAYNE A. HENDRICKSON

Hendrickson, Wayne

Email: wah2@cumc.columbia.edu
Phone: 212-305-3456
Fax: 212-305-7379
Location: BB- Rm. 203

University Professor, Investigator, Howard Hughes Medical Institute

Structural biology of macromolecules; diffraction and computational methods

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DAVID HIRSH

Hirsh, David

Email: dih1@cumc.columbia.edu
Phone: 212-851-4845
Fax: 212-854-1680
Location: ICRC Rm. 805

Professor of Biochemistry & Molecular Biophysics

Molecular genetics of endocytosis in C. elegans; Role of cytokines in the mammalian inflammatory and immune responses

 

OLIVER HOBERT

Hobert, Oliver

Email: or38@cumc.columbia.edu
Phone: 212-305-0063
Fax: 212-342-1810
Location: HHSC Rm. 726A

Professor Biochemistry & Molecular Biophysics, Investigator, Howard Hughes Medical Institute

Genetic programs that control neural development in C. elegans

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BARRY HONIG

Honig, Barry

Email: bh6@cumc.columbia.edu
Phone: 212-851-4651
Fax:  212-851-4650
Location: ICRC Rm. 115
(AUDIII - 1130 St. Nicholas Avenue)

Professor of Biochemistry and Molecular Biophysics, Director, Center for Computational Biology and Bioinformatics
Investigator, Howard Hughes Medical Institute

Computational approaches, based on both biophysics and bioinformatics, to study the structure and function of biological macromolecules

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THOMAS M. JESSELL

Jessell, Thomas M.

Email: tmj1@cumc.columbia.edu
Phone: 212- 305-1531
Fax: 212-568-8473
Location: HHSC-Rm.1013

Claire Tow Professor, Neuroscience, Biochemistry & Molecular Biophysics
Investigator, Howard Hughes Medical Institute, Co-director, Kavli Institute

Molecular mechanisms of neuronal differentiation, axon guidance, and cell recognition in vertebrate development

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ERIC R. KANDEL

Kandel, Eric R.

Email: erk5@cumc.columbia.edu
Phone: 212-305-4143
Fax: 212-543-5474
Location: P.I. Annex Rm. 663

University Professor, Neuroscience, Psychiatry, Physiology & Cellular Biophysics, Biochemistry & Molecular Biophysics, Investigator, Howard Hughes Medical Institute, Co-Director, Kavli Institute

Cell and molecular mechanisms of associative and non-associative learning in invertebrates and vertebrates

 

ARTHUR KARLIN

Karlin, Arthur

Email: ak12@cumc.columbia.edu
Phone: 212-305-5778
Fax: 212-305-5594
Location: P&S- 11th Fl. Rm. 401

Higgins Professor of Biochemistry and Molecular Biophysics and Neurology and Professor of Physiology and Cellular Biophysics; Director of Center for Molecular Recognition

Molecular mechanisms of receptor function

 

photo of Laura Landweber

Landweber, Laura

Email: lfl2124@cumc.columbia.edu
Phone: 212-305-3898
Lab Phone: 212-305-4680                
Fax: 212-305-7932
Location: HHSC Rm 714

Professor of Biochemistry & Molecular Biophysics and Biological Sciences

RNA-mediated epigenetics and genome reorganization during development, using the ciliate Oxytricha as a model; molecular evolution and origin of complex genetic systems and genome architectures

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Lomvardas, Stravos

Email: sl682@cumc.columbia.edu
Phone: 212-853-0410
Fax: 212-305-5594                
Location: 550 West 120th Street
NorthWest Corner Building Rm. 110

Professor of Biochemistry & Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute
Columbia University
Molecular mechanisms that generate the astounding diversity of cell types that characterise the mammalian nervous system. As a model system for our studies we use the olfactory system and the study of the epigenetic mechanisms regulating olfactory receptor (OR) gene choice.

Maniatis, Tom

Chairman

Email: tm2472@cumc.columbia.edu
Phone: 212-305-3669                              
Fax: 212-305-7932                                    Location: HHSC Rm. 616

Isidore S. Edelman Professor of Biochemistry, Director of University-wide Precision Medicine Initiative

Molecular and cellular mechanisms of gene regulation in the nervous system at the levels of signal transduction, transcription and RNA splicing.

 

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RICHARD S. MANN

Mann, Richard S.

Email: rsmann10@gmail.com
Phone: 212-305-7731
Fax: 212-305-7924
Location: HHSC Rm. 1104

Higgins Professor of Biochemistry & Molecular Biophysics

Control of pattern formation by homeotic genes and their downstream targets in Drosophila

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ARTHUR G. PALMER, III

Palmer, Arthur G. III
Vice Chair

Email: agp6@cumc.columbia.edu
Phone: 212-305-8675
Fax: 212-305- 6949                                Location: BB Rm. 504

Robert Wood Johnson Jr. Professor of Biochemistry & Molecular Biophysics

Structure, function, and dynamics of proteins, fluctuations in chemical and biological systems; and nuclear magnetic resonance and fluorescence spectroscopies

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BURKHARD ROST

Shapiro, Lawrence

Email: lawrenceshapiro@gmail.com
Phone: 212-342-6029                       
Fax: 212-342-6026                                    
Location: Russ Berrie Rm. 403

Professor, Columbia University, Department of Biochemistry and Molecular Biophysics and Edward S. Harkness Eye
Institute, Member of the Naomi S. Berrie Diabetes Center, Jules and Doris Stein Professor of Research to Prevent Blindness, RPB Foundation

Structural information obtained from X-ray crystallography to direct biochemical studies of biological problems, particularly involving neuronal cell adhesion and neural patterning


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Shaw, David

Email: des2119@cumc.columbia.edu
Phone: 212-478-0211                            
Location:120 W. 45th St., 39th Floor
New York, New York 10036

Adjunct Professor of Biochemistry and Molecular Biophysics (in Biomedical Informatics and Systems Biology)

Use of very long molecular dynamics simulations to study the structural changes in proteins associated with protein folding, protein-ligand binding, molecular signaling, ion transport, and other biologically significant processes.


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Peter Sims

Sims, Peter

Email: pas2182@cumc.columbia.edu
Phone: 212-851-5369                                
Fax: 212-342-6026                                    
Location: ICRC Bldg., Rm. 1002B

Assistant Professor, Columbia University,
Columbia Initiative for Systems Biology
Department of Biochemistry and Molecular Biophysics

We develop new technology for single cell analysis, focusing mainly on proteomics and transcriptomics.  By combining cutting-edge microscopy, next-generation sequencing, and microfabrication, we enable novel, unbiased measurements for investigation of heterogeneous biological systems


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Sobolevsky, Alexander

Email: as4005@cumc.columbia.edu
Phone: 212-305-4249

Fax: 212-305-7932

Location: BB Rm. 513

Assistant Professor, Columbia University, Department of Biochemistry and Molecular Biophysics

Studies of ion channel structure and function using biophysical and biochemical approaches including X-ray crystallography and electrophysiology.

 

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Tavazoie, Saeed

                       

Tavazoie, Saeed

Email: st2744@cumc.columbia.edu
Phone:+212-851-5166                          
Fax:212-305-7932                                    
Location: Russ Berrie-Rm. 405A

Professor of Biochemistry and Molecular Biophysics, Columbia Initiative in Systems Biology

 

Organizing principles underlying the evolution and function of molecular networks; predictive models of gene expression from sequence; elucidating regulatory perturbations in pathological states such as cancer; evolution of complex microbial behaviors; antibiotic tolerance pathways

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Chaolin Zhang

Zhang, Chaolin

Email: cz2294@cumc.columbia.edu                    
Phone: 212-305-9354
Fax: 212-342-4512
Location: P&S Bldg., Rm. 4-448

Assistant Professor, Columbia University, Columbia Initiative for Systems Biology
Department of Biochemistry and Molecular Biophysics

Development and application of novel experimental and computational approaches to studying RNA-regulatory networks in the mammalian brain and neurodegenerative diseases at the systems level.

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images/CharlesZukerPhoto_crop.JPG

                                                               

Zuker, Charles

Email: cz2195@columbia.edu
Phone:212-305-7819                                
Fax: 212-342-5747
Location: HHSC Rm. 517A

Professor, Columbia University, Departments of Biochemistry and Molecular Biophysics & Neuroscience,

Investigator, Howard Hughes Medical Institute

 

Charles Zuker's laboratory is using a combined molecular, genetic, and physiological approach to study signal processing, information transfer, and coding mechanisms in sensory systems.

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BUILDING ABBREVIATION

P&S: College of Physicians & Surgeons
BB: William H. Black Building
HHSC: Hammer Health Sciences Center