Research Faculty

David Paik, M.D.
Associate Research Scientist
Mail Address:

Dept. of Ophthalmology
Columbia University
630 West 168th Street
New York, NY 10032
Office Location:

Harkness Eye Institute
5th Floor, Room 508
635 West 165th Street
New York, NY 10032

Telephone: 212-305-1622
Fax: 212-305-7238
Email: dcp14@columbia.edu
Research Areas

Therapeutic Corneoscleral Cross-linking – we are developing a novel treatment for diseases involving corneoscleral destabilization such as keratoconus, post-LASIK keratectasias, and progressive myopia.

Bruch’s membrane damage in the pathogenesis of Age-related Macular Degeneration – we are examining the role of nitrite (from diet, smoking, and inflammation) induced cumulative damage to Bruch’s membrane in the development of inflammation, Drusen formation, and alterations in transmembrane exchange. 

Epidemiologic associations between dietary nitrite and age-related chronic non-cancer diseases – we are collaborating with epidemiologists to study the role of dietary nitrite (i.e. cured meats, etc.) in the development of chronic obstructive pulmonary disease and vascular stiffening.

 

Selected Awards and Honors

R21 EY018937 (Paik)

01/01/2009 - 12/31/2010

NIH/NEI
A Novel Treatment for Keratoconus and Keratectasias using Nitro Technology
To develop a novel treatment for corneal destabilization using topical application of
nitroalcohol compounds for therapeutic collagenous tissue cross-linking.

Columbia University

07/01/2008 - 06/30/2009

NIH/NCRR UL1RR024156
Irving Institute for Clinical and Translational Research/The Clinical Trials Office
2008 pilot study award (Paik)

K08 AG00863 (Paik)

03/01/2000 - 03/01/2005

NIH/NIA
Nitrite/Collagen Reactions in Aging and Smoking
The major goal of this project was to develop methods to detect biomarkers of
collagen nitration and apply such methods in the study of aged and diseased human tissues.

American Federation for Aging Research (AFAR) Research Grant (Paik)

1999 - 2001

The Non-Enzymatic Nitration of Collagen in Human Vascular Aging
The major goal of this project was to develop methods to detect biomarkers of
collagen nitration and apply such methods in the study of human aortic vascular stiffening.

Research Summary

Staff

Selected Recent Publications