Acne

What is acne?

Acne is a disorder of the hair follicles and sebaceous glands. The glands become clogged, leading to pimples and cysts.

Acne is very common - nearly 17 million people in the US are affected by this condition. Acne most often begins in puberty. During puberty, the male sex hormones (androgens) increase in both boys and girls, causing the sebaceous glands to become more active - resulting in increased production of oil (sebum).

How does acne develop?

The sebaceous glands produce sebum that normally travels via hair follicles to the skin surface. However, skin cells can plug the follicles, blocking the sebum coming from the sebaceous glands. When follicles become plugged, skin bacteria (called Propionibacterium acnes, or P. acnes) begin to grow inside the follicles, causing inflammation. Acne progresses in the following manner:

1. Incomplete blockage of the hair follicle results in blackheads (a semisolid, black plug).
2. Complete blockage of the hair follicle results in whiteheads (a semisolid, white plug). Infection and irritation cause whiteheads to form.

Eventually, the plugged follicle bursts, spilling oil, skin cells, and bacteria onto the skin surface. In turn, the skin becomes irritated and pimples or lesions begin to develop. The basic acne lesion is called a comedo.

Acne can be superficial (pimples without abscesses) or deep (when the inflamed pimples push down into the skin, causing pus-filled cysts that rupture and result in larger abscesses).

What causes acne?

Rising hormone levels during puberty may cause acne. In addition, acne is often inherited. Other causes of acne may include the following:

• hormone level changes during the menstrual cycle in women
• certain drugs (such as corticosteroids, lithium, and barbiturates)
• oil and grease from the scalp, mineral or cooking oil, and certain cosmetics
• bacteria inside pimples

Acne can be aggravated by squeezing the pimples or by scrubbing the skin too hard. Skin may also become irritated with friction or pressure from helmets, backpacks, or tight collars. Some environmental conditions such as pollution or humid conditions can also irritate the skin.

What are the symptoms of acne?

Acne can occur anywhere on the body. However, acne most often appears in areas where there is a high concentration of sebaceous glands, including the following:

• face
• chest
• upper back
• shoulders
• neck

The following are the most common symptoms of acne. However, each individual may experience symptoms differently. Symptoms may include:

• blackheads
• whiteheads
• pus-filled lesions that may be painful
• nodules (solid, raised bumps)

The symptoms of acne may resemble other skin conditions. Always consult your physician for a diagnosis.

Treatment of acne:

Specific treatment for acne will be determined by your physician based on:

• your age, overall health, and medical history
• severity of the acne
• your tolerance for specific medications, procedures, or therapies
• expectations for the course of the condition
• your opinion or preference

The goal of acne treatment is to minimize scarring and improve appearance. Treatment for acne will include topical or systemic drug therapy. Depending upon the severity of acne, topical medications (applied to the skin) or systemic medications (taken orally) may be prescribed by your physician. In some cases, a combination of both topical and systemic medications may be recommended.

Topical medications to treat acne:

Topical medications are often prescribed to treat acne. Topical medication can be in the form of a cream, gel, lotion, or solution. Examples include:

benzoyl peroxide	kills the bacteria (P. acnes)
antibiotics	helps stop or slow down the growth of P. acnes and reduces inflammation
tretinoin	stops the development of new acne lesions (comedones) and encourages cell turnover, unplugging pimples
adapalene	decreases comedo formation

Systemic medications to treat acne:

Systemic medications, or oral antibiotics, are often prescribed to treat moderate to severe acne, and may include the following:

• doxycycline
• erythromycin
• tetracycline

Treatment for severe, cystic, or inflammatory acne:

Isotretinoin (Accutane®), an oral drug, may be prescribed for individuals with severe, cystic, or inflammatory acne that cannot be effectively treated by other methods to prevent extensive scarring. Isotretinoin reduces the size of the sebaceous glands that produce the skin oil, increases skin cell shedding, and affects the hair follicles, thereby reducing the development of acne lesions. Isotretinoin can clear acne in 85 percent of patients. However, the drug has major unwanted side effects, including psychiatric side effects. It is very important to discuss this medication with your physician.

Isotretinoin must not be taken by women who are pregnant or who are able to become pregnant, because there is a very high likelihood of birth defects occurring in babies whose mothers took the medication during pregnancy. Isotretinoin can also cause miscarriage or premature birth. Because of these effects and to minimize fetal exposure, isotretinoin is approved for marketing only under a special restricted distribution program approved by the US Food and Drug Administration (FDA). This program is called iPLEDGE.

The goal of the iPLEDGE program is to prevent pregnancies in females taking isotretinoin and to prevent pregnant females from taking isotretinoin. Requirements of the iPLEDGE program include:

• Isotretinoin must only be prescribed by prescribers who are registered and activated with the iPLEDGE program.
• Isotretinoin must only be dispensed by a pharmacy registered and activated with iPLEDGE.
• Isotretinoin must only be dispensed to patients who are registered with and meet all the requirements of iPLEDGE
• Female patients who can get pregnant are required to use birth control for one month prior to treatment, during treatment, and for one month after stopping treatment.
• Pregnancy tests are required before, during, and after treatment.

Treatment for acne scars:

Specific dermatological procedures to minimize acne scars will be determined by your physician based on:

• your age, overall health, and medical history
• severity of the scar
• type of scar
• your tolerance for specific medications, procedures, or therapies
• your opinion or preference

Although acne often is a chronic condition, even if it lasts only during adolescence, acne can leave life-long scars. Acne scars typically look like "icepick" pit scars or crater-like scars. Although proper treatment for acne may help minimize scarring, several dermatological procedures may help to further minimize any acne scars, including the following:

• dermabrasion
  Dermabrasion may be used to minimize small scars, minor skin surface irregularities, surgical scars, and acne scars. As the name implies, dermabrasion involves removing the top layers of skin with an electrical machine that "abrades" the skin. As the skin heals from the procedure, the surface appears smoother and fresher.
• chemical peels
  Chemical peels are often used to minimize sun-damaged skin, irregular pigment, and superficial scars. The top layer of skin is removed with a chemical application to the skin. By removing the top layer, the skin regenerates, often improving the skin's appearance.
• collagen injections
  One type of collagen, which is derived from purified bovine (cow) collagen, is injected beneath the skin to replace the body's natural collagen that has been lost. Injectable collagen is generally used to treat wrinkles, scars, and facial lines.
• laser resurfacing
  Laser resurfacing uses high-energy light to burn away damaged skin. Laser resurfacing may be used to minimize wrinkles and fine scars.
• phototherapy/blue light therapy
  Phototherapy using a blue light source has been shown to decrease the number of acne-causing bacteria with minimal side effects, such as dry skin.  Blue light therapy does not use ultraviolet (UV) light, so it does not damage the skin as earlier types of light therapy did. According to the American Academy of Dermatology, blue-light therapy is the best-known light therapy for acne treatment.
• pulsed light and heat energy (LHE) therapy
  This type of combined light and heat therapy is believed to work by destroying acne-causing bacteria and by shrinking the oil-producing glands in the skin. The FDA has approved an LHE system that uses green light and heat pulses for treating mild to moderate acne.
• punch grafts
  Punch grafts are small skin grafts used to replace scarred skin. A hole is punched in the skin to remove the scar, which is then replaced with unscarred skin (often from the back of the earlobe). Punch grafts can help treat deep acne scars.
• autologous fat transfer
  An autologous fat transfer uses fat taken from another site on your own body and it is injected into your skin. The fat is placed beneath the surface of the skin to elevate depressed scars. This method is used to correct deep contour defects caused by scarring from nodulocystic acne. Because the fat may be reabsorbed into the skin over a period of months, there may be a need for the procedure to be repeated.