Stem cell and gene therapies, using human mesenchymal stem cells and selected gene constructs to develop biological pacemakers, perform myocardial repair and deliver therapies to targeted sites via siRNA technology;

Molecular biology, to identify and clone targets for new therapeutic interventions;

Structural biology, to visualize these targets in three dimensions;

Molecular modeling, to design novel molecules for activating or blocking these targets, that can serve as models for new drugs;

Transgenic technology, to modify targets in animals by either over-expressing or knocking them out, so that the role of each is identifiable in normal or abnormal physiologic function;

Membrane biophysics, to quantitatively assess the target and molecules designed to modify it in terms of kinetics and dynamics;

Biochemistry and signaling, to determine the signal transduction pathways that link stimulus to response, thereby improving our understanding of physiology and pathophysiology;

Translational physiology and electrophysiology, to help understand the expression of target function and its molecular modification in the pathophysiology, therapy and prevention of disease;

Clinical pharmacology, to test basic laboratory advances in clinical trials, so that their application to patient care becomes clearer.

Center Participants And Their Research | A Non-Traditional Center | Looking Forward Five Years | Supporting, Nurturing & Applying the Most Promising Ideas