Symplicity: Therapeutic renal denervation via the Symplicity Catheter as an alternative therapy for patients with uncontrolled, refractory hypertension

Short Description: This trial will look at renal denervation in the treatment of refractory hypertension (HTN). HTN is a major and growing global public health concern with an estimated 30-40% of adults suffering from this condition. Despite the availability of numerous safe and effective drugs that treat hypertension, the percentage of patients achieving adequate blood pressure control to guideline target values remains low, leaving uncontrolled patients at an increased cardiovascular risk. This is a multicenter study that will randomize 530 subjects 2:1 to renal denervation versus medication. Subjects who are randomized to medication who are still eligible for denervation at the end of the study will have the option to undergo the denervation procedure. Subjects will not know what treatment they were assigned. The target population are subjects on 3 maximum dose anti-HTN medications including 1 diuretic and have a BP>160.

Principal Investigator: Ajay Kirtane, MD Giora Weisz, MD




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