Toxicology

Caleb Ing, MD
Assistant Professor of Clinical Anesthesiology

Dr. Ing’s area of research deals with the examination of peri-operative and post-operative outcomes in children.  His current research looks at the long-term neurocognitive effects of anesthetics on infants and small children by using an established patient cohort.  His work centers around which neurodevelopmental outcomes may be affected by exposure to surgery and anesthesia as well as what types of exposure may be associated with long-term effects.  In addition, he is a collaborator in the Pediatric Anesthesia and NeuroDevelopment Assessment (PANDA) study, a prospective study looking at neurocognitive effects of surgery and anesthesia in children undergoing hernia repair.

 

 

Lena S. Sun, MD
Professor of Anesthesiology and Pediatrics

Dr. Sun’s research interests involve both the basic science as well as patient-oriented investigations. In the laboratory, she uses a rat model to examine the effect of prenatal cocaine exposure on postnatal sympathetic neural development and cardiovascular function. She employs a variety of techniques in her laboratory studies. They include the use of high fidelity echocardiography in small animals, the use of isolated organ preparations, and the application of immunocytochemical, biochemical, and molecular biological techniques. Her clinical research projects include the study of gender differences in the response of pediatric patients to noxious stimuli, myocardial ischemia and reperfusion and intravenous anesthetic agents.

 

Robert A. Whittington, MD
Associate Professor of Anesthesiology at CUMC

My current research interest primarily focuses on the impact of anesthesia and surgery on the neuropathogenesis of Alzheimer’s disease (AD).  Using transgenic mouse and cellular models of AD, my laboratory is investigating the impact of prolonged anesthesia exposure on the development of tau protein-related neurofibrillary pathology, one of the neuropathological hallmarks of Alzheimer’s.  The long-term goal of this research is to better understand how anesthesia and surgery modulate AD-related neuropathogenic pathways in order to identify perioperative treatment strategies that preserve cognitive function in those patients who are at risk for postoperative cognitive decline as well as incident dementia.

 


 

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Columbia University Medical Center Department of Anesthesiology