Zirka Anastasian, MD
Assistant Professor of Clinical Anesthesiology
Dr. Anastasian’s research interests focus on perioperative and intraoperative predictors of postoperative patient outcome including intraoperative blood pressure management, fluid management, and anesthetic management. She is currently collaborating on prospective clinical studies related to neurocognitive outcome as well as evaluating the effects of predictors of outcome using multi-center databases.
Mitchell F. Berman, MD
Professor of Clinical Anesthesiology
Dr. Berman's primary research interest is in outcome studies involving large computerized clinical and administrative databases. He is the administrator and designer of the anesthesia intraoperative data collection network and database at Columbia, a data source used for clinical research projects by researchers in the anesthesiology department and by other researchers at the University and Hospital.
The Department of Anesthesiology at Columbia University is one of the main participants in the national MPOG research database housed at the University of Michigan (Multicenter Perioperative Outcomes Group). Dr. Berman is one of the primary collaborators in the MPOG research consortium.
Dr. Berman also maintains a strong interest in the ergonomics and design of anesthesia monitoring equipment, and the integration of electronic medical recordkeeping. He collaborates with the biomedical engineering department at the Hospital to select monitoring equipment and to design the mounting of patient monitors and computerized recordkeeping equipment onto the anesthesia workstation.
Eric J. Heyer, MD, PhD
Professor of Clinical Anesthesiology and Clinical Neurology
Dr. Heyer’s principal research is to elucidate mechanisms of surgical-associated cerebral injury that manifests itself as cerebral dysfunction determined by performance on a battery of neuropsychometric tests. The types of surgery associated with cerebral dysfunction are cardiac operations in which patients undergo cardiopulmonary bypass and vascular operations in which carotid endarterectomy is performed. The immediate goals are to document the incidence of cerebral injury, determine appropriate measures of injury, and postulate mechanisms that produce injury. Subsequently, strategies to ameliorate cerebral injury will be formulated and tested that will involve intraoperative procedures and cerebral protective medications.
Dr. Joshi's main research interest is the delivery of drugs by the intraarterial route to treat brain diseases. To do so the laboratory uses cutting edge optical methods to track drugs and tracers and monitor their physiological effects in whole animal models. Funded by the National Cancer Institute, the laboratory is the center of a multi-institutional research program optical engineers and pharmaceutical researchers in several universities. By using optical sensing and imaging methods such as, diffuse reflectance spectroscopy, ultraviolet spectroscopy, multispectral imaging, hyper-spectral imaging, optical coherence tomography, and infrared thermal imaging, the laboratory is developing novel drug delivery methods and drug formulations for the intraarterial treatment of brain cancer, stroke and cerebral vasospasm.