lung research

Jennifer Danielsson, MD
Assistant Professor of Anesthesiology
Publications

Dr. Danielsson’s main area of research focuses on investigating the role of calcium-activated chloride channels in the treatment of asthma and acute bronchospasm.  Perioperative bronchospasm in the OR and ICU remains an important clinical problem for anesthesiologists.  As poorly controlled asthma is a major risk factor for acute bronchospasm, novel treatments for asthma that could both relieve acute bronchospasm and control chronic manifestations such as airway hyperresponsiveness, increased mucus secretion and increased inflammation, are greatly needed.  Her research focuses on investigating calcium-activated chloride channel’s role in cell signaling events associated with the pathogenesis of asthma.

 

 

 

 

 

 

Jeanine D'Armiento, MD, PhD
Associate Professor of Medicine and Anesthesiology
Publications

The major goal of my research program is to develop insight into lung physiology and pathology through understanding the mechanisms altering lung injury and repair and translating these findings into practical clinical solutions. My research studies mainly focus on the role of matrix metalloproteinases (MMP) in normal physiology and in human disease integrating both in vitro and in vivo approaches. My laboratory is also uniquely situated to characterize the molecular changes in the study of smoke-induced injury and disease so as to identify potential therapeutic targets for smoke induced disease processes.

 

 

 

 

Charles W. Emala, MD
Professor of Anesthesiology
Publications

Dr. Emala's main area of research interest is in the understanding of interactions between signal transduction pathways in airway nerves and smooth muscle and how these interactions contribute to diseases such as asthma. Interaction of anesthetic agents with muscarinic and GABA receptors on airway nerves and smooth muscle is a particular focus of these studies. A broader understanding of the non-neuronal expression and function of GABAA receptors in smooth muscle is a central focus.  The laboratory uses whole animal airway physiology studies, isolated contractile studies of airway and vascular smooth muscle and biochemical and molecular biological techniques in elucidating the expression and function of signaling molecules.

 

 

George Gallos, MD
Assistant Professor of Anesthesiology
Publications

My research interests includes mechanisms of smooth muscle relaxation, in particular the role GABAA channels may play in modulating airway smooth muscle and uterine smooth muscle relaxation.

 

 

 

 

 

 

Monica Goldklang, MD
Assistant Professor of Anesthesiology at CUMC
Publications

Dr. Goldklang’s main area of research interest is in translational studies investigating the pathogenesis of smoking related lung disease. Her work involves understanding the mechanisms of protease upregulation in lung injury. She is currently working on a project investigating factors that alter MMP-13 expression and activity in lung disease. Moving forward, Dr. Goldklang has received NIH K08 funding to investigate the role of ion channels in smoking related lung disease. A broader understanding of intracellular calcium regulation, through BK channel and ryanodine receptor function, in lung injury is a central focus of this work. 

 

 

 

 

 

 

Laurence Ring, MD 
Assistant Professor of Anesthesiology

Dr. Laurence Ring’s research focuses on acute lung injury that may be caused by invasive positive pressure ventilation.  About one third of critically ill patients require invasive ventilatory support and about a quarter of those patients are thought to develop ventilator associated lung injury (VALI).  In the time since the significance of this injury was recognized (ARDSNet Trial, 2000), strategies to treat or avoid the injury, namely the use of positive end expiratory pressure and a low tidal volume approach to ventilation, have become engrained in critical care and intraoperative medicine.  However, despite these interventions, the disease still persists.  In an attempt to gain a better understanding of the molecular biology underlying VALI, Dr. Ring’s current research centers on the development of a mouse model of ventilator associated lung injury.  The mouse model will serve to identify novel pathways activated in VALI which may serve as therapeutic or prophylactic targets.  We eventually hope to begin testing protocols and compounds in ventilated mice which will have the potential to reduce morbidity and mortality from VALI in humans.

 

 

Tom Yocum, MD
Assistant Professor of Anesthesiology
Publications

Dr. Yocum is interested in the function of GABA-A receptors expressed on non-neuronal cells, particularly immune cells, and how anesthetics modulating these receptors may alter immune function.  In pursing these interests, our lab studies inflammatory allergic lung disease using whole animal models and in vitro studies of immune cell function, cell signaling, and electrophysiology.   A second interest is selective pharmacologic targeting of GABA-A receptors on airway smooth muscle cells to treat bronchoconstriction.


 

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Columbia University Medical Center Department of Anesthesiology