lung research

Jeanine D'Armiento, MD, PhD
Associate Professor of Medicine and Anesthesiology

The major goal of my research program is to develop insight into lung physiology and pathology through understanding the mechanisms altering lung injury and repair and translating these findings into practical clinical solutions. My research studies mainly focus on the role of matrix metalloproteinases (MMP) in normal physiology and in human disease integrating both in vitro and in vivo approaches. My laboratory is also uniquely situated to characterize the molecular changes in the study of smoke-induced injury and disease so as to identify potential therapeutic targets for smoke induced disease processes.





Charles W. Emala, MD
Professor of Anesthesiology

Dr. Emala's main area of research interest is in the understanding of interactions between signal transduction pathways in airway nerves and smooth muscle and how these interactions contribute to diseases such as asthma. Interaction of anesthetic agents with muscarinic and GABA receptors on airway nerves and smooth muscle is a particular focus of these studies. A broader understanding of the non-neuronal expression and function of GABAA receptors in smooth muscle is a central focus.  The laboratory uses whole animal airway physiology studies, isolated contractile studies of airway and vascular smooth muscle and biochemical and molecular biological techniques in elucidating the expression and function of signaling molecules.




George Gallos, MD
Assistant Professor of Anesthesiology

My research interests includes mechanisms of smooth muscle relaxation, in particular the role GABAA channels may play in modulating airway smooth muscle and uterine smooth muscle relaxation.


Columbia University Medical Center Department of Anesthesiology