The Research Division of the Department of Anesthesiology conducts a broad range of epidemiological, clinical and basic science research. Clinical and basic scientists closely collaborate in translational research in a wide array of research activities including (1) health services policy and outcomes research; (2) pharmacogenetics of cognitive dysfunction; (3) pharmacogenetics of pre-term labor, labor pain and labor progression; (4) anesthetic effects on pediatric neurocognitive development; (5) anesthetic effects on Alzheimer-related proteins; (6) mechanisms of protection for ischemia-reperfusion injury of kidney and liver; (7) clinical biomarkers of perioperative organ injury (brain, heart, liver, kidney); (8) ion channel electrophysiology; (9) neuronal mechanisms of narcotic analgesia, tolerance and addiction; (10) cellular signaling mechanisms of airway, vascular and uterine smooth muscle function; (11) lung injury, remodeling and fibrosis (12) intra-arterial delivery of therapeutics to the brain; (13) modulation of clinical inflammatory pain via nicotinic acetylcholine receptors; (14) alcohol effects on GABAA signaling and glial cell gene expression; (15) perioperative cognitive dysfunction; (16) efficacy of transcutaneous electrical nerve stimulation in chronic pain; (17) electronic medical data acquisition and medical informatics.
Clinical research studies include patients in the operating rooms, neuroradiology suites, intensive care units and pain clinic. State-of-the-art laboratory facilities allow for studies ranging from whole animal physiology to subcelluar molecular studies.
The Research Division actively recruits residents and fellows interested in academic careers and offers support through the Virginia Apgar Fellowship and National Institutes of Health T32 Fellowship Training Grant in the development of anesthesiologists as physician scientists. Individual faculty research interests are described under research topic subheadings linked from this page.