Eric J. Hall, D.Phil.

Special Lecturer in Radiation Oncology
Special Research Scientist
Higgins Professor of Radiation Biophysics, emeritus

Center for Radiological Research

Contact Information: 

Center for Radiological Research
630 W. 168th Street
VC 11-230
New York, NY 10032

Telephone (212) 305-5660
Fax: (212) 305-3229

Email: ejh1@columbia.edu

Education

BSc, University College, London, UK, 1953
DPhil, Radiobiology, Oriel College, Oxford University, Oxford, UK, 1962

Research

Dr. Hall concentrates on two principal objectives, both of which require an understanding of the basic biology of the interaction of radiation with living cells. These are: 1) research into mechanisms of the carcinogenic and mutagenic effects of low doses of radiation and; and 2) research in support of radiation therapy.

The first objective is aimed toward understanding the deleterious effects of low doses of radiation. We are constantly exposed to low level of radiation, from natural sources such as radon, to man-made sources including nuclear power and medical x-rays. Present risk estimates are based on data from the survivors of Hiroshima and Nagasaki, who were exposed to large doses at high dose-rate. The extrapolation of risk estimates to environmental situations requires an understanding of basic mechanisms of radiation carcinogenesis. Our research efforts have focused on the use of the single particle microbeam to investigate mutation and oncogenic transformation in cells of human origin resulting from the passage of a single charged particle.

The second objective is directed toward improvements in the use of radiotherapy for the treatment of cancer. More than half of all cancer patients receive radiotherapy at some stage in the management of their disease. Translational research include initiatives in low dose-rate and pulsed brachytherapy, the interaction of x-rays with paclitaxel, studies of genetic determinants of radiosensitivity as it relates to patients who suffer late effects from radiation treatment and clinical trials of new treatment and diagnostic protocols.

Selected Activities

Fellow of the American College of Radiology, 1981

Fellow of the Royal College of Radiology, 1999

Fellow of the Society of Radiological Protection, 2004

Fellow of the American Society of Therapeutic Radiology & Oncology, 2006

Publications

Brenner DJ, Sachs RK, Peters LJ, Withers HR, Hall EJ. We Forget at Our Peril the Lessons Built into the α/β Model. Int J Radiat Oncol Biol Phys 82, 1312-1314, 2012.

Zhou, G., Smilenov, L.B., Lieberman, H.B., Ludwig, T. and Hall, E.J. Radiosensitivity to high energy iron ions is influenced by heterozygosity for Atm, Rad9 and Brca1. Adv Space Res 46, 681-686, 2010.

Su, F., Smilenov, L.B., Ludwig, T., Zhou, L., Zhu, J., Zhou, G. and Hall, E.J. Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis. Radiat Oncol 5, 15, 2010.

Hall, E.J., Protons for radiotherapy:a 1946 proposal. Lancet Oncol 10, 196, 2009.

Hall, E.J., Metting, N., Puskin, J. and Ron, E. Low dose radiation epidemiology: what can it tell us? Radiat Res 172, 134-138, 2009.

Hall, E.J.  Cancer caused by x-rays - a random event? Lancet Oncol 8, 369-370, 2007.

Hall, E.J., Is there a place for quantitative risk assessment? J Radiol Protect 29,  A171-A184, 2009.

Hall, E.J. and Brenner, D.J. Cancer risks from diagnostic radiology. Br J Radiol 81, 362-78 2008.

Kleiman, N.J., David, J., Elliston, C.D., Hopkins, K.M., Smilenov, L.B., Brenner, D.J., Worgul, B.V., Hall, E.J. and Lieberman, H.B. Mrad9 and ATM haploinsufficiency enhance spontaneous and x-ray-induced cataractogenesis in mice. Radiat Res 168, 567-73, 2007.

Hall, E.J., Worgul, B.V., Smilenov, L., Elliston, C.D., Brenner, D.J. The relative biological effectiveness of densely ionizing heavy-ion radiation for inducing ocular cataracts in wild type versus mice heterozygous for the ATM gene.  Radiat Environ Biophys 45, 99-104, 2006.

Hall, E.J., Intensity-Modulated radiation therapy, protons, and the risk of second cancers. Int J Radiation Biol Phys 65, 1-7, 2006.

Honors and Awards

MA, Honoris Causa, Oriel College, Oxford University, Oxford, UK, 1966

DSc, Honoris Causa, Oriel College, Oxford University, Oxford, UK, 1977

The Janeway Medal, American Radium Society, 1992

Gold Medal, American Society of Therapeutic Radiology & Oncology, New Orleans, 1993

Juan del Regato Gold Medal Award, MD Anderson Cancer Center, Houston, TX, 1997p>

John B. Little Award, Harvard School of Public Health, Boston, MA, 2000

Henry S. Kaplan Distinguished Scientist Award, 12th International Congress of Radiation Research, 2003

Distinguished Scientific Achievement Award, 50th Annual Meeting Health Physics Society, 2005

Gray Medal, International Commission on Radiological Protection (ICRP), 2007