Publications

MEGAN SYKES:

Sachs DH, Kawai T, Sykes M. Induction of Tolerance Through Mixed Chimerism. In: Turka L, Wood K, editors. Cold Spring Harbor Perspectives; 2013. 2014 Jan 1;4(1):a015529. doi: 10.1101/cshperspect.a015529.

Haspot F, Li HW, Lucas CL, Fehr T, Beyaz S, Sykes M. Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells. American Journal of Transplantation, 2014 Jan 14(1): 49-58. doi: 10.1111/ajt.12525. PMID: 24304495. PMCID: PMC4045013.

Griesemer A, Yamada K, Sykes M. Xenotransplantation: Immunological hurdles and progress toward tolerance. Immunological Reviews; 2014 Mar;258(1):241-58. doi: 10.1111/imr.12152. PMID: 24517437. PMCID: PMC4023346.

Sykes M. Transplantation: Moving to the Next Level. Immunological Reviews; 2014. 2014 Mar;258(1):5-11. doi: 10.1111/imr.12161. PMID: 24517422. PMCID: PMC4038030.

Sykes M. Transplantation Immunology. In: The Cecil Text Book of Medicine, 25th Edition. (Eds), Goldman L, Ausiello, D. Philadelphia, PA; Saunders Elsevier; 2014; (In Press)

Kalscheuer H, Onoe T, Dahmani A, Holzl M, Yamada K, Sykes M. Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts. Journal of Immunology, 2014 Apr 1;192(7):3442-50. doi: 10.4049/jimmunol.1302886. PMID: 24591363. PMCID: PMC3983999.

Li H, Yang YG, Sykes M. Thymic education of human T cells and regulatory T cell development in humanized mice. In: Humanized Mice for HIV Research; Poluektova LY, Garcia-Martinez JV, Koyanagi Y, Manz MG, Tager AM (Ed.), New York, NY, Springer Science+Business Media; 2014; 10: (page number to be determined) (In Press)

Kawai T, Sachs DH, Sprangers B, Spitzer T, Saidman S, Zorn E, Tolkoff-Rubin N, Preffer F, Crisalli K, Gao B, Wong W, Morris H, LoCascio S, Sayre P, Shonts B, Williams W, Smith R, Colvin R, Sykes M, Cosimi A. Long-Term Results in Recipients of Combined HLA-Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression. American Journal of Transplantation. 2014 June 5; XX:1-13. doi: 10.1111/ajt.12731. PMID: 24903438.

H. Morris, S. DeWolf, H. Robins, B. Sprangers, S. A. LoCascio, B. A. Shonts, T. Kawai, W. Wong, S. Yang, J. Zuber, Y. Shen, M. Sykes, Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients. Sci. Transl. Med. 7, 272ra10 (2015).

MARCUS MAPARA:

Phase 1/2 Study of Ocaratuzumab, an Fc-Engineered Humanized Anti-CD20 Monoclonal Antibody, in Low-Affinity FcγRIIIa Patients with Previously Treated Follicular Lymphoma. Ganjoo KN, de Vos S, Pohlman BL, Flinn IW, Forero-Torres A, Enas NH, Cronier DM, Dang NH, Foon KA, Carpenter SP, Slapak CA, Link BK, Smith MR, Mapara MY, Wooldridge JE. Leuk Lymphoma. 2014 Jul 14:1-7. [Epub ahead of print] PMID: 24717109 [PubMed - as supplied by publisher] PMCID IN PROGRESS

Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. Choi SW, Braun T, Chang L, Ferrara JL, Pawarode A, Magenau JM, Hou G, Beumer JH, Levine JE, Goldstein S, Couriel DR, Stockerl-Goldstein K, Krijanovski OI, Kitko C, Yanik GA, Lehmann MH, Tawara I, Sun Y, Paczesny S, Mapara MY, Dinarello CA, DiPersio JF, Reddy P. Lancet Oncol. 2014 Jan;15(1):87-95. doi: 10.1016/S1470-2045(13)70512-6. Epub 2013 Nov 30. PMID: 24295572 [PubMed - indexed for MEDLINE] PMCID: PMC4103793

REMI CRUESOT:

Creusot RJ, Giannoukakis, N, Trucco M, Clare-Salzler MJ, Fathman CG (2014) It’s time to bring dendritic cell therapy to Type 1 Diabetes. Diabetes 63(1): 20-30. PMID: 24357690 [PubMed - indexed for MEDLINE] PMCID: PMC3968436.

Yip L, Fuhlbrigge R, Taylor C, Creusot RJ, Matsumura T, Whiting C, Schartner JM, Akter R, Von Herrath M, Fathman CG (2015) Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during Type 1 diabetes. Diabetes. 64(2): 604-617.

Johannesson B, Sui L, Freytes D, Creusot RJ, Egli D (2015) Towards beta cell replacement for diabetes. EMBO Journal. In press.

HANS SNOECK:

Huang SX, Islam MN, O’Neill J, Hu Z, Yang Y-Y, Chen Y-W, Green MD, Mumau M, Vunakc-Novakovic G, Bhattacharya J, Snoeck HW. (2014) Highly efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol., 32:84-91. PMID: 24291815 [PubMed - in process] PMCID: PMC4101921

Kamezaki K, Snoeck HW. (2014) Differential requirement of wild-type Flt3 in leukemic stem cells which is not reflected in vitro assays for leukemic stem cells. Exp Hematol, 32:84-91.

Baker SJ, Ma’ayan A, Lieu YK, John P, Reddy MVR, Chen EY, Duan Q, Snoeck HW, Reddy EP. (2014) B-myb is Essential Regulator of Hematopoietic Stem Cell and Myeloid Progenitor Cell Development. Proc. Natl. Acad Sci USA, 111:3122-3127. PMID: 24516162 [PubMed - indexed for MEDLINE] PMCID: PMC3939923.

Huang SX, Green M, Toste A, Mumau M, Chen YW, Snoeck HW. Protocol of for the generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Protocols, in press.

Ciancanelli M, Huang SX, Luthra P, Garner H, ITan Y, Volpi S, Trouillet C, Schmolke M, Isrealsson E, Herman M, Hermesh T, Lorenzo L, Albrecht RA, Leung LW, Okada S, Picard C, Ringuier B, Troussier F, Chaussabel D, Abel L, Pellier I, Notarangelo LD, Garcai-Sastre A, Basler CF, Geissmann F, Zhang SY, Snoeck HW, Casanova JL. Impaired innate and intrinsic IFNα/β amplification underlies life-threatening influenza in human inherited IRF7 deficiency. Science (accepted pending minor revisions)

XIAOJUAN CHEN:

Liao S, Mei J, Song W, Chi S, Liu Y, Chen X, Deng S. The impact of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) fasting glucose diagnostic criterion on the prevalence and outcomes of gestational diabetes mellitus in Han Chinese women. Diabetic Medicine 2014; 31(3)341-51; Epub 2013 Nov 22 PMID: 24152069 [PubMed - in process] PMCID IN PROGRESS.

RAIMON DURAN-STRUUCK:

Vascularized composite allograft tolerance across MHC barriers in a large animal model. Leonard DA, Kurtz JM, Mallard C, Albritton A, Duran-Struuck R, Farkash EA, Crepeau R, Matar A, Horner BM, Randolph MA, Sachs DH, Huang CA, Cetrulo CL Jr. Am J Transplant. 2014 Feb;14(2):343-55. doi: 10.1111/ajt.12560. Epub 2014 Jan 9. PMID: 24405666 [PubMed - in process] PMCID: PMC3971524.

 

WAICHI WONG:

Ferdman J, Porcheray F, Gao B, Moore S, Devito J, Dougherty S, Thomas M, Farkash E, Elias N, Kawai T, Malek SY, Tullius S, Wong W, Zorn E. Expansion and somatic hypermutation of B cell clones in rejected human kidney grafts. Transplantation, 2014 May 12 [epub].

Gao B, Moore C, Porceray F, Rong C, Abidoglu C, DeVito J, Paine R, Girouard TC, Saidman SL, Schoenfeld D, Levin B, Wong W, Elias N, Schuetz C, Rosales I, Fu Y, Zorn E. Am J Transplant, in press.

ADAM GRIESEMER:

Griesemer A, Yamada K, Sykes M. Xenotransplantation: immunological hurdles and progress toward tolerance. Immunological Reviews. Immunol Rev. 2014 Mar;258(1):241-58. PMID: 24517437

Weiner J, Wu J, Martinez M, Lobritto S, Ovchinsky N, Rohde C, Griesemer A, Kato T. The use of bi-planar tissue expanders to augment abdominal domain in a pediatric intestinal transplant recipient. Pediatric Transplantation. 2014 Aug: 18(5): E174–E179, PMID: 25041331.

Halazun KJ, Patzer RE, Rana AA, Verna EC, Griesemer AD, Parsons RF, Samstein B, Guarrera JV, Kato T, Brown RS Jr, Emond JC. Standing the test of time: Outcomes of a decade of prioritizing patients with HCC, results of the UNOS natural geographic experiment. Hepatology. 2014 Jun 20. PMID: 24954365.

Wang H, Griesemer AD, Parsons RF, Graham JA, Emond JC, Samstein B. Delayed gastric emptying after living donor hepatectomy for liver transplantation. Case Rep Transplant. 2014;2014:582183. PMCID: PMC4291134.

Case Rep Transplant. 2014;2014:582183.

YONGGUANG YANG:

Huang SXL, Islam MN, O’Neil J, Hu Z, Yang YG, Chen YW, Mumau M, Green MD, Vunjak-Novakovic G, Battachariya J, Snoeck HW. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014;32(1):84-91. doi: 10.1038/nbt.2754. Epub 2013 Dec 1.

Wang H, Yang YG. The complex and central role of interferon- in graft-versus-host disease and graft-versus-tumor activity. Immunol Rev. 2014 Mar;258(1):30-44. NIHMSID # 579492.

Wang Y, Wang H, Ren L, Weng Q, Bao Y, Tian H, Yang YG*, Li X*. Non-mitogenic form of acidic fibroblast growth factor protects against graft-versus-host disease without accelerating leukemia. Int Immunopharmacol. 2014 Sep 16. pii: S1567-5769(14)00347-6. doi: 10.1016/j.intimp.2014.09.006.

Hu L, Cheng H, Gao Y, Shi M, Liu Y, Hu Z, Xu J, Qiu L, Yuan W, Leung AY, Yang YG, Cheng T. The antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice. Blood. 2014 Oct 6. pii: blood-2014-03-559369.

Li HW, Yang YG, Sykes M. Thymic Education of Human T Cells and Regulatory T Cell Development in Humanized Mice (Chapter 11). In: Humanized Mice for HIV Research; Springer Science New York (In Press).

Hu Z, Yang YG. Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice (Chapter 5). In: Humanized Mice for HIV Research; Springer Science New York (In Press).

DONNA FARBER:

Turner, D.L., Bickham, K.L., Thome, J.J.T., Kim, C., D’Ovidio, F., Wherry, E.J. and Farber, D.L. (2014) Lung resident niches for the generation and maintenance of influenza-specific memory T cells. Mucosal Immunology. 7:501-10.

Farber, D.L. , Yudanin, N.A. and Restifio, N.P. (2014) Human Memory T cells: generation, compartmentalization and homeostasis. Nature Reviews Immunology.14:24-35. (featured on cover)

Turner, D.L., Gordon, C.L. and Farber, D.L. (2014) Tissue resident T cells, in situ immunity and transplantation. Immunol. Reviews. 258:150-166.

Subramanian, M., Hayes, C.D., Thome, J.J., Thorp, E., Matsushima, G.K., Herz, J., Farber, D.L., Liu, K., Lakshmana, M. and Tabas, I. (2014) A Multiprotein Complex of Axl, LRP-1, and RanBP9 Mediates Dendritic Cell Efferocytosis and Antigen Cross-Presentation In Vivo. J. Clin. Invest. 124:1296-308.

Zens, K.D. and Farber, D.L. (2014) Memory CD4 T cell responses to influenza virus. Current Topics in Microbiology and Immunology. [Epub ahead of print].

Turner, D.L. and Farber, D.L. (2014) Mucosal resident memory CD4 T cells in protection and immunopathology. Front. Immunol. 5:331

Camirand, G., Wang, Y., Lu, Y. Wan, Y.Y., Lin, Y., Deng, S., Guz, G., Perkins, D.L., Finn, P.W., Farber, D.L., Flavell, R.A., Shlomchik, W.D., Lakkis, F.G., Rudd, C.E., and Rothstein, D.M. (2014) CD45 Ligation increases antigen-mediated expansion of regulatory T cell by promoting interactions with dendritic cells in vivo. J. Clin. Invest. In Press.

Thome, J.J.C., Yudanin, N.A., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y. and Farber, D.L. (2014) Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell. In Press.

Brestoff,J.R., Kim,B.S., Saenz,S.A., Stine,R.R., Monticelli,L.A., Sonnenberg,G.A., Thome,J.J.T., Farber,D.L., Lutfy,K., Seale, P., and Artis, D. (2014) Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit diet-induced obesity. Nature, doi: 10.1038/nature14115.
Yu, M., Owens, D.M., Ghosh, S. and Farber, D.L. (2015) Conditional PDK1 ablation promotes epidermal and T cell-mediated dysfunctions leading to inflammatory skin disease. J. Invest. Derm. In Revision

Thome, J.J.C., Bickham, K.L., Kubota, M. Ohmura, Y., Lerner, H., Kato, T., and Farber, D.L. (submitted) Regulatory T cells shape human mucosal and lymphoid T cell responses during infancy.

EMMANUEL ZORN:

Gao B, Moore C, Porcheray F, Rong C, Abidoglu C, DeVito J, Paine R, Girouard TC, Saidman SL, Schoenfeld D, Levin B, Wong W, Elias N, Schuetz C, Rosales I, Fu Y, Zorn E. Pretransplant IgG reactivity to apoptotic cells correlates with late kidney allograft loss. Am J Transplant. 2014 Jul;14(7):1581-91. doi: 10.1111/ajt.12763. Epub 2014 Jun 16. PMID: 24935695

Kawai T, Sachs DH, Sprangers B, Spitzer TR, Saidman SL, Zorn E, Tolkoff-Rubin N, Preffer F, Crisalli K, Gao B, Wong W, Morris H, LoCascio SA, Sayre P, Shonts B, Williams WW Jr, Smith RN, Colvin RB, Sykes M, Cosimi AB. Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression. Am J Transplant. 2014 Jul;14(7):1599-611. doi: 10.1111/ajt.12731. Epub 2014 Jun 5. PMID: 24903438

Ferdman J, Porcheray F, Gao B, Moore C, DeVito J, Dougherty S, Thomas MV, Farkash EA, Elias N, Kawai T, Malek SK, Tullius SG, Wong W, Zorn E. Expansion and Somatic Hypermutation of B-cell Clones in Rejected Human Kidney Grafts. Transplantation. 2014 May 12. [Epub ahead of print] PMID: 24825521

Mengel M, Chong A, Rothstein DM, Zorn E, Maltzman JS. AST Cutting Edge of Transplantation 2013 Meeting Report: a comprehensive look at B cells and antibodies in transplantation. Am J Transplant. 2014 Mar;14(3):524-30. doi: 10.1111/ajt.12593. Epub 2014 Jan 24. PMID: 24674597