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Yong-Guang Yang, MD, PhD

  • Professor of Medical Sciences (in Medicine)
Yong-Guang Yang, MD, PhD

Dr. Yang is a Professor of Medical Sciences at Columbia University. He received his PhD in Immunology in 1991 from Norman Bethune University of Medical Sciences, China. Dr. Yang spent about one and a half years (1992-1994) as a Visiting Scientist at the Mitsubishi Kagaku Institute of Life Sciences, Japan where he worked on molecular cloning of porcine T-cell receptors. He did his postdoctoral training in Transplantation Immunology in Dr. Megan Sykes’ laboratory in the Transplantation Biology Research Center at the Massachusetts General Hospital/Harvard Medical School in Boston (1994-1997). Dr. Yang then worked as an Instructor, Assistant Professor, and Associate Professor in the Department of Surgery at Massachusetts General Hospital/Harvard Medical School for 13 years, and joined the Faculty at Columbia University and the Columbia Center for Translational Immunology in 2010.

Dr Yang’s research involves allogeneic and xenogeneic transplantation immunology, stem cell transplantation, and humanized mouse models

Transplantation Immunology: Graft rejection and tolerance induction; GVHD and GVT effects; Humanized mouse models.

Departments and Divisions

  • Department of Medicine

Centers / Institutes / Programs

  • Herbert Irving Comprehensive Cancer Center

NIH Grants

  • ELUCIDATING GENETICS OF RESPONSE TO IMMUNE CHECKPOINT BLOCKADE IN LUNG CANCER (Federal Gov)

    Jan 18 2017 - Dec 31 2021

    A TOLERANCE APPROACH TO XENOTRANSPLANTATION (Federal Gov)

    Aug 1 2017 - Jul 31 2021

    MICE WITH AUTOLOGOUS HUMAN T1D-DERIVED IMMUNE SYSTEMS AND IPSC-DERIVED BETA CELL (Federal Gov)

    Sep 25 2014 - Jun 30 2019

    STUDYING HUMAN DENDRITIC CELLS AND DC-SIGN IN HIV TRANSMISSION IN VIVO USING AN IMPROVED HUMANIZED MOUSE MODEL (Federal Gov)

    Feb 1 2017 - Feb 28 2019

    IMPROVING ENGRAFTMENT AND SURVIVAL OF PIG ISLET XENOGRAFTS THROUGH TRANSGENIC EXPRESSION OF HUMAN CD47 (Private)

    Mar 1 2017 - Feb 28 2018

    ROLE OF CD47 IN XENOGRAFT REJECTION BY MACROPHAGES (Federal Gov)

    Apr 1 2005 - Feb 28 2018

    TOLERANCE-INDUCING PROPERTIES OF HUMAN DENDRITIC CELL SUBSETS IN VIVO (Federal Gov)

    Feb 1 2015 - Jan 31 2018

    TOLERANCE FOR XENOGENEIC ISLET CELL TRANSPLANTATION IN NON-HUMA (Private)

    Feb 1 2017 - Aug 31 2017

    CORE C: SMALL ANIMAL CORE, A TOLERANCE APPROACH TO XENOTRANSPLANATION (Federal Gov)

    Jul 15 2011 - Jun 30 2016

    PIG TO HUMAN THYMIC XENOTRANSPLANTATION (Federal Gov)

    May 1 2010 - Apr 30 2016

    CHARACTERIZATION OF HUMAN IMMUNE CELL DEPLETION BY GENZYME COMPOUND DRUGS IN HUMANIZED MICE (Private)

    Jan 1 2012 - Mar 14 2013

    CHARACTERIZATION OF HUMAN IMMUNE CELL DEPLETION BY GENZYME C OMPOUND DRUGS IN HUMANIZED MICE (Private)

    Jan 1 2012 - Dec 31 2012

    GVL WITHOUT GVHD ACROSS HLA BARRIERS: TRANSLATIONAL STUDIES (Federal Gov)

    Sep 12 2006 - Jul 31 2012

    IMMUNE RESPONSE TO ALLOGENEIC HESC-DERIVES ENDOTHELIAL CELLS (Federal Gov)

    Apr 21 2010 - Mar 31 2012

    ROLE OF CD47-SIRPALPHA SIGNALING IN A LIVER CELLS XENOGRAFT REJECTION (Private)

    Jul 1 2010 - Jun 30 2011

Publications

(Selected from >100 papers)

Zhang M, Wang H, Tan S, Navarro-Alvarez N, Zheng Y, Yang YG. Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation. Sci Reports 2016 (In Press).

Wu H, Zhen Y, Xu ZG, Ma Z, Li H, Yu J, Wang XY, Yi H, Yang YG. Arginase-1-dependent promotion of Th17 differentiation and disease progression by MDSCs in systemic lupus erythematosus. Sci Transl Med. 2016 Mar 23;8(331):331ra40. doi: 10.1126/scitranslmed.aae0482.

Hu Z, Xia J, Fan W, Wargo J, Yang YG. Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice. Oncotarget 2016;7(6):6448-6459. doi: 10.18632/oncotarget.7044. [Epub ahead of print].

Pan Y, Wang F, Liu Y, Jiang J, Yang YG (co-senior author), Wang H. Studying the mechanism of CD47-SIRPα interactions on red blood cells by single molecule force spectroscopy. Nanoscale. 2014;7:6(17):9951-4. doi: 10.1039/c4nr02889a.

Wang H, Yang YG. The complex and central role of interferon-g in graft-versus-host disease and graft-versus-tumor activity. Immunol Rev. 2014 Mar;258(1):30-44. NIHMSID # 579492

Rong Z, Wang M, Hu Z, Stradner M, Zhu S, Kong H, Yi H, Goldrath A, Yang YG, Xu Y, Fu X. An effective approach to prevent immune rejection of human ESC-derived allografts. Cell Stem Cell 2014;2:14(1):121-30. doi: 10.1016/j.stem.2013.11.014. PMCID: PMC4023958.

Hu Z, Yang YG. Full reconstitution of human platelets in humanized mice after macrophage depletion. Blood 2012;120(8):1713-6. Epub 2012 Jul 6. PMCID: PMC3429310.

Yang Y, Wang H, Yu H, Yeap BY, Liang T, Wang G, Cheng T, Yang YG. IFN-g promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation. Blood 2011;118(13):3721-4. Epub 2011 Aug 11. PMCID: PMC3186344.

Hu Z, van Rooijen N, Yang YG. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 2011;118(22):5938-46. Epub 2011 Sep 16. PMCID: PMC3228505.

Wang H, Wu X, Wang Y, Oldenborg PA, Yang YG. CD47 is required for suppression of allograft rejection by donor specific transfusion.  J Immunol. 2010;184:3401-3407. PMCID: PMC3670954

Ide K, Wang H, Liu J, Wang X, Asahara T, Sykes M, Yang YG (co-senior author), Ohdan H. Role for CD47-SIRPa signaling in xenograft rejection by macrophages. Proc Natl Acad Sci USA 2007;104(12):5062-5066. PMCID: PMC1829264

Wang H, Madariaga ML, Wang S, Van Rooijen N, Oldenborg PA, Yang YG.  Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells.  Proc Natl Acad Sci USA 2007;104:13744-13749. PMCID: PMC1949343

Yang YG, Sykes M. Xenotransplantation - Current Status and a Perspective on the Future. Nature Reviews Immunology 2007;7:519-531.

Wang H, VerHalen J, Madariaga ML, Xiang S, Wang S, Lan P, Oldenborg P-A, Sykes M, Yang YG.  Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood 2007;109:836-842. PMCID: PMC1785095

Lan P, Tonomura N, Wang S, Yang YG.  Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation.  Blood 2006;108:487–492.