Columbia University Medical Center (CUMC) scientists have developed a way to recreate an individual's immune system in a mouse.Wednesday, March 14, 2012Columbia University Medical Center (CUMC) scientists have developed a way to recreate an individual's immune system in a mouse. The "personalized immune mouse" offers researchers an unprecedented tool for individualized analysis of abnormalities that contribute to type 1 diabetes and other autoimmune diseases...Dr. Megan Sykes featured in the Spring, 2011 edition of CUMC's P&S Magazine in "Reimagining Organ Transplantation", by Susan Conova.P&S Magazine, Spring 2011Thursday, August 4, 2011Dr. Sykes discusses the CCTI's commitment to the strategy of preventing attacks on donated organs by the creation of a chimeric immune system within the transplant patient; one that is part donor and part recipient.Anette Wu, MD, PhDFriday, July 1, 2011Induction of Liver Allograft Tolerance through Bone Marrow Transplantation: Translational Preclinical Pilot Study in MonkeysNichole M. Danzl, PhDFriday, July 1, 2011Cell intrinisc immunopathology of type 1 diabetes in a humanized mouse modelHiroyuki Tahara MD, PhDFriday, July 1, 2011There is a critical shortage of allogeneic organs. A more elegant, long-term solution is to use transplantation from other species. However, unresolved questions exsist concerning the susceptibility of xenografts to severe rejection and its mechanism.