Donated organs are helping researchers map out the immune system in humans.- By Amanda B Keener at The ScientistSaturday, August 1, 2015
Monday, June 8, 2015
The Columbia Center for Translational Immunology is honored to welcome two esteemed colleagues to the center, Dr. David H. Sachs, MD and Dr. Kazuhiko Yamada, MD, PhD who will be joining us this summer.
Dr. Sachs, who won the 2014 Medawar prize for his pioneering work in tolerance induction and xenotransplantation, established the Transplantation Biology Research Center (TBRC) at Massachusetts General Hospital/Harvard Medical School, where he has been the Paul S. Russell/Warner-Lambert Professor of Surgery since 1991.
Dr. Yamada, an outstanding large animal transplantation immunologist, was the Senior Investigator/Head, Organ Transplantation Tolerance & Xenotransplantation Laboratory at the MGH Center for Transplantation Sciences and Director of Surgical Research at the TBRC Laboratories and an Associate Immunologist at Massachusetts General Hospital and Associate Professor of Surgery at Harvard Medical School.
Friday, June 5, 2015
Dr. Xiaojuan Chen awarded the
Monday, February 9, 2015
We are delighted to announce two of the six inaugural winners of the Department of Medicine’s Samuel Bard Young Investigator Awards are members of the CCTI! The following fellows will present abstracts of their research at Medicine Grand Rounds on the two Research Days for Clinical and Post-doctoral Fellows and Scientists 2014.
On Wednesday, March 11, 2015:
Ya-Wen Chen, PhD, Post-doctoral Research Scientist, Division of Pulmonary, Allergy, & Critical Care Medicine: Modeling human branching morphogenesis in vivo
Larry Luchsinger, PhD, Post-doctoral Research Fellow, Division of Molecular Medicine: Mitochondrial Dynamics Regulate Hematopoietic Stem Cell Function
to the CCTI's Dr. Adam GriesemerWednesday, February 4, 2015
The Irving Institute for Clinical and Translational Research awarded 16 faculty members Irving Institute/Clinical Trials Office Pilot Awards, which provide junior faculty with funds to conduct pilot studies needed to attract future independent funding and our own Dr. Adam Griesemer has been chosen as one of the 2014 awardees!
Thursday, January 29, 2015
Nature Biotech highlighted our paper on twitter: https://twitter.com/NatureBiotech/status/560574101128237056
"Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients"in Science Translational MedicineWednesday, January 28, 2015
When a patient receives a transplant, a unique population of T lymphocytes emerges to reject the foreign organ. Immunosuppressive medication is therefore necessary to prevent rejection and protect the transplanted kidney. Previously, it had not been possible in humans to identify these specific T cells due to their vast number and diversity; furthermore, this population is unpredictable and distinct for each transplant patient and his or her organ donor. In this paper, we describe a new technique to identify these thousands of T cells before the time of kidney transplantation and then track them over time after transplant circulating in peripheral blood. We used this technique to study six kidney transplant recipients to investigate in a new way what happens to these cells when patients have different clinical outcomes. Some of the patients studied were part of a unique cohort who received combined kidney and bone marrow transplants from the same donor in order to induce tolerance and accept their grafts without life-long immunosuppressive medication. Our T cell tracking analysis provided a deeper understanding of the mechanism of tolerance in these patients. This new technique provides a window into the fate of these donor-specific T cells and has potential as a possible biomarker for predicting and identifying rejection and tolerance in different types of transplant patients.
Project: The Immune Privilege of the Hematopoietic Stem Cell NicheMonday, January 26, 2015
Dr. Joji Fujisaki, MD. PhD, was recently awarded a prestigious 2015 Schaefer Research Scholar Award by Columbia University, the selection for which is based upon “outstanding merit for the proposed research and as carried out in the past year; along with the likelihood of outstanding future research. See this link for more information about Dr. Fujisaki's research.
Dr. Donna Farber, et alThursday, November 6, 2014
Mechanisms for human memory T cell differentiation and maintenance have largely been inferred from studies of peripheral blood, though the majority of T cells are found in lymphoid and mucosal sites. We present here a multidimensional, quantitative analysis of human T cell compartmentalization and maintenance over six decades of life in blood, lymphoid, and mucosal tissues obtained from 56 individual organ donors. Our results reveal that the distribution and tissue residence of naive, central, and effector memory, and terminal effector subsets is contingent on both their differentiation state and tissue localization. Moreover, T cell homeostasis driven by cytokine or TCR-mediated signals is different in CD4+ or CD8+ T cell lineages, varies with their differentiation stage and tissue localization, and cannot be inferred from blood. Our data provide an unprecedented spatial and temporal map of human T cell compartmentalization and maintenance, supporting distinct pathways for human T cell fate determination and homeostasis. Click here for the full paper published in the most recent issue of Cell.
Dr. Adam Griesemer receives grant from the Irving Institute/Clinical Trials Office (CTO) Pilot Award for 2014Friday, October 10, 2014
Clinical Trials Office Pilot Award from the Irving Institute for Translational Research for a grant entitled: "Combined liver and bone marrow transplantation for the induction of tolerance to liver allografts". The goal of this study is to induce tolerance to liver allografts in a preclinical cynomolgus monkey model through the co-transplantation of donor bone marrow and an enhanced immunological conditioning regimen.