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New publication in Science Immunology

Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome

Science Immunology has published the CCTI's latest manuscript, "Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome" first-authored by Dr. Julien Zuber, and as senior author, CCTI director Dr. Megan Sykes. The findings describe how Graft-versus-Host and Host-versus-Graft memory T cells can take up long-term residency in human intestinal allograft mucosa and the dynamics of the two-way alloimmune response correlate with graft outcomes. View the paper on the Science Immunology web site here.