Dr. Donna Farber's lab has published a study of the distribution and function of natural killer cells across various human tissues, revealing anatomic control of their development as well as populations that mediate immunosurveillance systemically.
Highresolution map of human NK cells shows tissue-driven distribution across ages
Differentiated NK cells predominate in blood, bone marrow, spleen, and lungs
Tissueresident NK cells exhibit specific adaptations in mucosal and lymphoid sites
Lymph nodes and intestines are reservoirs for precursor and immature NK cells