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Intranasal Flu Vaccine Produces Long-Lasting Immune Response in Mice

CCTI Associate Director Dr. Donna Farber and her lab have shown intranasal flu vaccines may be able to provide long-lasting protection against pandemic flu strains. Dr. Farber's found that, in mice, the intranasal flu vaccine FluMistTM (Medimmune) led to the production of T cells in the lungs that provided long-term protection against multiple flu strains, including those that were not present in the vaccines. Mice given the traditional injectable vaccine, such as FluzoneTM (Sanofi Pasteur), did not produce these cells.
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