The latest issue of the journal Immunity features "Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life" by Tomer Granot, et al of Dr. Donna Farber's lab. Some highlights include:
- Human cDC1 and cDC2 subset distribution is a function of tissue site;
- cDC2s exhibit maturation and migration phenotypes in mucosal-draining lymph nodes;
- Mature cDC2s accumulate in lymph node interfollicular zones;
- Localized cDC subset distribution and maturation is largely retained over life.
For the complete article, please go to the Immunity page here.