Farber Lab Publishes in latest issue of Cell Reports

Dr. Donna Farber and her lab have published "Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway" in the latest issue of Cell Reports. Some hiighlights:

  • The human pancreas contains CD8+ TRMs exhibiting tissue-specific molecular signatures;

  • Pancreas TRMs express high levels of PD-1 yet maintain strong effector function;

  • During homeostasis, pancreas TRMs are regulated by PD-L1+ tissue macrophages;

  • In chronic pancreatitis, TRM PD-1 levels and PD-L1+ macrophage density are reduced

Read the full paper via link below:

https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31538-4