Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients
in Science Translational Medicine
When a patient receives a transplant, a unique population of T lymphocytes emerges to reject the foreign organ. Immunosuppressive medication is therefore necessary to prevent rejection and protect...
Project: The Immune Privilege of the Hematopoietic Stem Cell Niche
Dr. Joji Fujisaki, MD. PhD, was recently awarded a prestigious 2015 Schaefer Research Scholar Award by Columbia University, the selection for which is based upon “outstanding merit for the...
Dr. Donna Farber, et al
Mechanisms for human memory T cell differentiation and maintenance have largely been inferred from studies of peripheral blood, though the majority of T cells are found in lymphoid and mucosal...
Dr. Adam Griesemer receives grant from the Irving Institute/Clinical Trials Office (CTO) Pilot Award for 2014
Clinical Trials Office Pilot Award from the Irving Institute for Translational Research for a grant entitled: "Combined liver and bone marrow transplantation for the induction of tolerance to...
New York-Presbyterian/Columbia University Medical Center has opened the Irving Bone Marrow Transplant Unit, a state-of-the-art facility for comprehensive bone marrow transplant (BMT) care.
American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Avoidance of long-term immunosuppression is a desired goal in organ transplantation. Mixed chimerism offers a promising approach to tolerance induction, and we have aimed to develop low-toxicity,...
Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets
Immunity, December 2012
Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown.
Dr. Sykes speaks to WNYC's "The Takeaway"
The latest research in autoimmune disease and cancer treatment is doing just that: using mice as stand-ins to study exactly how an individual’s cells work, and how and why they respond to certain...
By Andrew Pollack, New York Times
Dr Megan Sykes speaks to the New York Times about the benefits and challenges of the Humanized Mouse Model.
"If Gandhi were a stem cell, which would he be?" by Holly Wobma
Dr. Megan Sykes, Director of the Columbia Center for Translational Immunology, finds them so interesting. She wants to use these cells to teach a patient’s body to become tolerant to the cells of...