American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Avoidance of long-term immunosuppression is a desired goal in organ transplantation. Mixed chimerism offers a promising approach to tolerance induction, and we have aimed to develop low-toxicity,...
Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets
Immunity, December 2012
Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown.
Dr. Sykes speaks to WNYC's "The Takeaway"
The latest research in autoimmune disease and cancer treatment is doing just that: using mice as stand-ins to study exactly how an individual’s cells work, and how and why they respond to certain...
By Andrew Pollack, New York Times
Dr Megan Sykes speaks to the New York Times about the benefits and challenges of the Humanized Mouse Model.
"If Gandhi were a stem cell, which would he be?" by Holly Wobma
Dr. Megan Sykes, Director of the Columbia Center for Translational Immunology, finds them so interesting. She wants to use these cells to teach a patient’s body to become tolerant to the cells of...
By Ben Coxworth - Gizmag.com
Because everyone’s immune system is different, it’s impossible to predict with absolute certainty how any given person will react to a specific medication.
In Genetic Engineering & Biotechnology News
Scientists report on the development of a mouse model that recapitulates the immune system of a single adult human.
A Science Translational Medicine Paper
Studies of human immune diseases are generally limited to the analysis of peripheral blood lymphocytes of heterogeneous patient populations.
Columbia University Medical Center (CUMC) scientists have developed a way to recreate an individual's immune system in a mouse.
Dr. Megan Sykes featured in the Spring, 2011 edition of CUMC's P&S Magazine in "Reimagining Organ Transplantation", by Susan Conova.
Dr. Sykes discusses the CCTI's commitment to the strategy of preventing attacks on donated organs by the creation of a chimeric immune system within the transplant patient; one that is part donor...