Emmanuel Zorn, Ph.D.

 

Dr. Zorn is an Assistant Professor of Clinical Sciences at Columbia University. Dr. Zorn received a Ph.D. in tumor immunology from Paris University in 1999 for his studies on human melanoma antigens. He then joined Dana-Farber Cancer Institute in Boston, MA, where he studied the role of regulatory T cells in chronic graft versus host disease in humans. Dr. Zorn setup his research laboratory at the Massachusetts General Hospital Transplant Center in 2006 to work on human kidney graft rejection. He moved to the CCTI at Columbia University Medical Center in 2014, where he now directs a human transplantation immunology research laboratory. He is also the Director of the CCTI Biobank core. The primary focus of Dr. Zorn’s lab is on B cells and antibodies in mechanisms of rejection or acceptance of kidney and heart transplants.

 

Selected Publications:

Gao B, Moore C, Porcheray F, Rong C, Abidoglu C, DeVito J, Paine R, Girouard TC, Saidman SL, Schoenfeld D, Levin B, Wong W, Elias N, Schuetz C, Rosales I, Fu Y, Zorn E. Pretransplant IgG reactivity to apoptotic cells correlates with late kidney allograft loss. Am J Transplant. 2014 Jul;14(7):1581-91. doi: 10.1111/ajt.12763. Epub 2014 Jun 16. PMID: 24935695

Kawai T, Sachs DH, Sprangers B, Spitzer TR, Saidman SL, Zorn E, Tolkoff-Rubin N, Preffer F, Crisalli K, Gao B, Wong W, Morris H, LoCascio SA, Sayre P, Shonts B, Williams WW Jr, Smith RN, Colvin RB, Sykes M, Cosimi AB. Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression. Am J Transplant. 2014 Jul;14(7):1599-611. doi: 10.1111/ajt.12731. Epub 2014 Jun 5. PMID: 24903438

Ferdman J, Porcheray F, Gao B, Moore C, DeVito J, Dougherty S, Thomas MV, Farkash EA, Elias N, Kawai T, Malek SK, Tullius SG, Wong W, Zorn E. Expansion and Somatic Hypermutation of B-cell Clones in Rejected Human Kidney Grafts. Transplantation. 2014 May 12. [Epub ahead of print] PMID: 24825521

Mengel M, Chong A, Rothstein DM, Zorn E, Maltzman JS. AST Cutting Edge of Transplantation 2013 Meeting Report: a comprehensive look at B cells and antibodies in transplantation. Am J Transplant. 2014 Mar;14(3):524-30. doi: 10.1111/ajt.12593. Epub 2014 Jan 24. PMID: 24674597

 Porcheray, F, Fraser JW, Gao B, McColl A, DeVito J, Dargon I, Helu Y, Wong W, Girouard TC, Saidman SL, Colvin RB, Palmisano A, Maggiore U, Vaglio A, Smith RN and Zorn E. Polyreactive Antibodies Developing Amidst Humoral Rejection of Human Kidney Grafts Bind Apoptotic Cells and Activate Complement. American J. Transplant. 2013. 13:2590-600. PMCID: PMC3864117.