Dr. Jianing Fu was granted an International Transplantation Science Mentee-Mentor Award for her research paper, "Differing Mechanisms for Early Versus Persistent Donor T cell Chimerism in Peripheral Blood of Human Intestinal Transplant Recipients". Mixed lymphocyte reaction and high throughput TCRb CDR3 DNA sequencing were used to identify alloreactive T cell clones, and they were further tracked in blood or allograft post-transplant. The data demonstrated that donor graft-versus-host-reactive T cells and hematopoietic stem cells and progenitor cells carried within the graft play a key role in promoting and maintaining donor chimerism in the peripheral blood, which correlates with better clinical outcomes. This study provides new insights into the underlying mechanism of blood mixed chimerism and paves the way to develop new strategies to reduce graft rejection and achieve tolerance.
Dr. Fu received her BS and MS on Pharmaceutical Sciences and Chemical Biology from Peking University in China, and PhD on Cancer Biology and Immunology from University of South Florida and H. Lee Moffitt Cancer Center. She is now a postdoctoral research scientist at the Columbia Center for Translational Immunology at Columbia University. Under Dr. Megan Sykes’s mentorship, Dr. Fu’s research is aimed at decoding the bidirectional alloreactivity after intestinal transplantation and investigating the phenotype and function of gut hematopoietic stem cells and progenitors, with the ultimate goal of eliminating graft rejection by inducing long persistent blood mixed chimerism.
The award will be given out during the Transplantation Science Networking Event on Thursday, May 25th during the 15th Annual Transplantation Science Symposium (TSS2017) in Victoria, BC, Canada.