Past Research Projects

R24 HL76857 (PI: K.W. Davidson, T.P. Pickering)                         2004-2009            $3,455,642
Mind-Body-Behavioral Medicine Clinical Trials Infrastructure

This project involves the development of infrastructure that will allow interdisciplinary study of the effects of stress and psychological dimensions on hypertension and heart disease.  The major goal is to address five barriers that have impeded the impact of mind-body (behavioral) medicine in the general medical community.
R01 HL80665 (PI: K. Davidson)                                                       2005-2010                $475,297
CAD Incidence: Depression and Inflammation Risk
This project will determine if depression and inflammatory status are independent or dependent markers of CHD incidence risk.
N01 HC25197 (PI: K. Davidson)                                                      2002-2009           $13,735,665
Consortium for the Translation of Psychosocial Depression Theories to Intervention and Dissemination 

The major goals of this contract are to understand the etiology, course, and treatment of the dysphoria following an acute coronary syndrome.
Project 1: Etiologies of Cardiac Depression
Tests the applicability of psychological proximal causes of depression to dysphoric, post-ACS patients
Project 2: Phase I Depression RCT for post-ACS patients
Explores patient acceptability, safety, and efficacy of depression intervention
Project 3: Medication Adherence as a Mediator of Depression-ACS Relation
Tests potential behavioral and physiological mediators in depression - ACS relation
K23 HL072866 (PI: D. Shimbo)                                                        2003-2009                $774,225

Translational Studies of Hostility, Atherothrombosis & CAD
The goals of this research program are to examine the relationship between hostility and its management on levels of inflammatory markers and platelet reactivity.
(PI: T. Pickering)                                                                               2008                $95,993
Microlife, Inc.                                                
New Ways of Measuring Blood Pressure in Clinical Practice
The purpose of this study is to compare the BP readings taken by 3 various devices against 24 hour ABPM readings and the conventional physicians’ readings using a mercury sphygmomanometer.
(PI: T. Goyal-Spruill)                                                                       2006-2009                  $75,000
Telephone-Based Lifestyle Intervention to Reduce Blood Pressure in Pre-Hypertensive Patients
The goal is to test the effect of a 4-session telephone-based lifestyle intervention on blood pressure change in pre-hypertensive patients.
(PI: D. Shimbo)                                                                                  2006-2009                  $45,000
Victoria and Ester Aboodi Sponsorship
Electro-Mechanical Coupling In the Diseased Left Ventricle
The major goal of this study is to determine the relation between mechanical activation (using 3D echocardiography) and electrical activation (3D CARTO mapping) in patients with heart failure.
(PI: D. Shimbo)                                                                                  2006-2009                  $45,000
Victoria and Ester Aboodi Sponsorship
Echocardiographic Vv Optimization of Sequential Biventricular Pacing In Patients with Advanced Heart Failure
The major goal of this study is to determine the utility of 3D echocardiography in optimizing the VV delay in heart failure patients who have received a sequential biventricular pacer.
R01 HL67439 (PI: W. Gerin)                                                             2001-2006             $3,362,146 
NIH/NHLBI                                                                                         (one-year NCE to 2007)

A Stepped Intervention for Meds Adherence and Blood Pressure Control
The major goals of this project are to test the effects of two commercially available interventions (Self-Telemonitoring and Telephone-Based Nurse Case Management) on medication adherence in hypertensive patients, and on blood pressure control, using an RCT pre-post design. 
Postdoctoral Minority Supplement (Lisa Lewis)                          2004-2006                $195,305
The aim is to allow Dr. Lewis to develop an instrument to assess spirituality in hypertensive African American patients.
Graduate Minority Supplement (Devon Dyett)                              2003-2005                  $76,956
The aim is for Mr. Dyett to assess the rate at which patients enrolled in this trial adopt non-pharmacologic approaches to treatment such as dietary changes, the awareness of physicians of dietary lifestyle changes (specifically the DASH diet) and finally the rate at which patients were recommended non-pharmacologic approaches by their physicians.
R01 HL73495 (PI: T. Pickering)                                                       2002-2007             $1,940,301
NIH/NHLBI                                                                                         (one-year NCE to 2007)

Conditioned Placebo Effects and Treatment of Hypertension
The goal of this project is to test the hypothesis that placebo pills given to lower blood pressure will have a greater effect if given after the active medication than before it.
NLM 03-3504 (PI: K. Davidson)                                                       2002-2007             $1,823,679
Summer Institute on Randomized Clinical Trials Involving Behavioral Intervention

The objectives of this effort are to provide a thorough grounding in the conduct of randomized clinical trials to researchers and health professionals interested in developing competence in the planning, design, and execution of clinical trials involving behavioral interventions.
R44 HL67584 (PI: L. Clemow)                                                          2001-2005             $1,117,084

Randomized Controlled Trial of the LifeSkills Workshop on Hypertensive Employees.
This goal of this study is to conduct a randomized controlled trial of the Williams LifeSkills workshop in a hospital setting.  We hypothesize that employees who undertake the LifeSkills workshop will show improved blood pressure, psychosocial risk factors, and decreased costs associated with treatment. 
R01 HL69408 (PI: G. Ogedegbe)                                                     2001-2005                $888,749

Motivational Interviewing in Hypertensive African-Americans
The goal of this project is to test the effectiveness of a motivational interview in improving medication adherence.  We will conduct a randomized controlled trial in 190 poorly controlled hypertensive African Americans followed in a primary care practice.
Graduate Minority Supplement (Emeka Ogu)                               2002-2005                  $15,734
The aim is to allow Mr. Ogu to investigate the various factors that may help African Americans who were diagnosed with high blood pressure to adhere to a regime of taking their antihypertensive medications.
K23 HL04458 (PI: K. Davidson)                                                       2001-2006                $643,680

Controlled Randomized Anger Reduction in Hypertensives
The major aim of this project is to test the feasibility of comparing an anger management group plus usual medical care to two control conditions-usual medical care only and another group therapy (time management) plus usual medical care.
Post-baccalaureate Minority Supplement (Seun Akinola) 2004-2005                           $50,533
On N01 HC25197 (PI: K. Davidson) 
The goal is to allow Mr. Akinola to go through all phases of a research project, including: creating a protocol to designing forms, conducting assays, developing a database, entering data, data analysis, preparing and submitting a publishable manuscript.
Post-baccalaureate Minority Supplement (Johanna Pineiro) 2006-2007        $48,300
On R01 HL078566 (PI: G. Ogedegbe)
The aim is for Ms. Pineiro to examine the relationship of patient expectation of outcomes and blood pressure among hypertensive African American patients receiving care in community health centers.
GCRC-Irving Center (PI: D. Shimbo)                                               2004                         $10,000
Inflammatory Markers, Endothelial Function, and Anger
The major goal of this project is to determine the effects of an anger-recall task on inflammatory markers, and endothelial function. This project will serve as a pilot study to conduct a large mechanism and treatment study on the effects of anger on CAD event risk.
P01 HL088117 (PI: K. Davidson) 2008-2014 (NCE) $12,479,004
Depression, Biobehavioral Mechanisms, & CHD/Mortality Outcomes

The goal of this study is to explain the increased prognostic risk in depressed cardiac patients for major adverse cardiac events &/or all-cause mortality by dissecting depression into key psychological & biological components & correlates.
To inquire about the use of final research data for research purposes, please contact the applicable Principal Investigator (PI) via