Current Research Projects
P01 HL47540 (PI: J.E. Schwartz, T.P. Pickering) 1993-2015 (NCE) $12,419,085
Psychosocial Factors and Cardiovascular Disease
This Program Project represents a continuation of our existing Program Project, which has been supported by NHLBI since 1985, and comprises a body of work that focuses on the role of psychosocial factors in the development of hypertension and cardiovascular disease. These projects focus on a set of inter-related themes concerning the causes and consequences of sustained blood pressure elevation.
Project 1: Masked Hypertension: A Prospective Study of the Development of Hypertension
This study will continue our investigation of MHT through 5-year follow-up exams to assess whether MHT leads to development of essential HT, progression of CV target organ damage (TOD), and increased risk of CV disease (CVD).
Project 2: Psychophysiological Mechanisms in Masked Hypertension
This study will examine physiological and psychological factors associated with delayed post-stress BP recovery, the process we hypothesize contribute to the high daytime BP that is characteristic of MHT.
Project 3: Improving the Detection of Hypertension: A Diagnostic Research Study
The long-term goal of this study is to improve the detection of HT, including those with MHT, so that treatment decisions are better informed, progression of TOD is slowed, and cardiovascular risk reduced.
K23 HL098359 (PI: I. Kronish) 2010-2016 (NCE) $135,947
Uncontrolled Hypertension: The Role of Clinical Inertia and Medication Adherence
This patient-oriented research award tests the effectiveness of a pilot intervention to improve clinician management of hypertension by electronically monitoring adherence to blood pressure medications and then providing clinicians with quantitative reports summarizing patient adherence.
R01 HL117323 (PI: D. Shimbo) 2014-2016 (NCE) $303,886
Incorporation of a Hypertension Working Group into the Jackson Heart Study
The goals of this study are to examine biological pathways involved in hypertension and in ambulatory blood pressure monitoring data from the Jackson Heart Study.
R01 HL115941 (PI: K. Davidson and M. Burg) 2012-2015 (NCE) $1,353,233
Ecological Link of Psychosocial Stress to Exercise: Personalized Pathways
The goal of this study is to test whether personalized models of stress and exercise better aid us in decreasing stress, and improving regular exercise behavior than traditional between-subject models.
R01 HL117832 (PI: D. Edmondson) 2013-2018 $3,155,309
Impact of Social-Interpersonal Factors in the ER on PTSD/Cardiac Outcomes
The goal of this study is to identify modifiable emergency department and interpersonal factors associated with poor medical and psychological prognosis in ACS patients.
K24 HL125704 (PI: D. Shimbo) 2015-2020 $3,458,334
Midcareer Investigator Award in Patient-Oriented Research in Human Hypertension
The overall goals of this program are to investigate the behavioral, psychosocial and biological processes in the pathogenesis of human hypertension, as well as train the next generation of scientists in hypertension research.
K24 HL084034 (PI: K. Davidson) 2006-2016 $910,075
Midcareer Mentoring in Behavioral Cardiology: Depression & Cardiovascular Disease
The goals of this study are to determine the point prevalence of underlying medical conditions known to cause depression and excess CHD recurrence/mortality in a large cohort of post-ACS patients and to determine if any of medical confounds explain some of the excess risk of depression for CHD recurrence/mortality controlling for standard covariates.
ECRIP (PI: K. Davidson) 2014- 2016 $796,608
Innovation Center for Improving 30-day Readmission and Patient Satisfaction: HPR iSCRIPT Center
The goal of this study is to identify novel hospital system, care processes, and patient factors that adversely influence 30-day readmissions. Additionally, this study will test strategies that alter these predictive factors, so as to simultaneously decrease 30-day readmission rates and increase patient satisfaction with care.
SC14-1403-12304 (PI: K. Davidson) 2014-2017 $1,049,741
Engaging Stakeholders in Building Patient-centered, N-of-1 Randomized and Other
The aims of this research are to conduct focus groups and then a large, national survey of patients to better understand the settings in which N-of-1 randomized control trial (NCT) are most needed for patients, the barriers and facilitators to their conduct. As well as, create educational materials to inform patients of the pros and cons of these trials, and determine which directions these methods should take to be most useful to patients.
R01 HL114924 (PI: K. Davidson) 2013-2018 $3,819,703
Depression Screening RCT in ACS patients: Quality of Life and Cost Outcomes
The goal of this study is to examine in a randomized controlled trial the benefits and costs of the American Heart Association’s advisory for depression screening and treatment of post-ACS patients.
R01 HL116470 (PI: D. Shimbo) 2013-2018 $629,503
Translational Research of Negative Emotions and Acute Endothelial Dysfunction
The aims of this study are to primarily examine the acute effects of provoked anger and secondarily depressed mood and anxiety on endothelial cell health.
Supplement PI: K. Diaz 2014 - 2018 $452,002
The primary aims of this study are to examine whether the harmful effects of negative mood on blood vessel health can be buffered by higher levels of cardiorespiratory fitness and daily physical activity.
Supplement PI: D. Mota 2015-2018 $70,644
The aims of this study are to primarily examine the acute effects of provoked anger and secondarily depressed mood and anxiety on endothelial cell health. A laboratory-based, randomized controlled experiment is used to test whether provoked anger, depressed mood and anxiety will induce endothelial dysfunction in humans.
R01 HL123368 (PI: I. Kronish) 2014-2018 $1,835,510
PTSD, Medication Adherence, and Prognosis after Acute Coronary Syndromes
The goal of this ancillary study is to identify a target for intervention after an acute coronary syndrome (ACS) that may decrease risk for recurrent cardiac events and mortality among patients who develop posttraumatic stress disorder (PTSD) due to the ACS.
R01 HL128310 (PI: W. Whang) 2015-2019 $2,604,529
Test of a new theory to explain excess risk in cardiac PTSD
This study tests a new theory to explain the excess risk associated with posttraumatic stress disorder (PTSD) due to non ST-elevation myocardial infarction and unstable angina; the two most common forms of acute coronary syndrome.