Current Research Projects

RC2 HL101663 (PI: K. Davidson)                                                    2009-2011       $4,136,888     
NIH/NHLBI                                                                                                    
Comparison of Depression Interventions After Acute Coronary Syndrome (CODIACS)
This is a proposal for a multicenter feasibility/vanguard project comparing the effectiveness of two interventions for post-ACS depression.
 
P01 HL47540 (PI: J.E. Schwartz, T.P. Pickering)                          1993-2014           $12,419,085
NIH/NHLBI                                                                                        
Psychosocial Factors and Cardiovascular Disease

This Program Project represents a continuation of our existing Program Project, which has been supported by NHLBI since 1985, and comprises a body of work that focuses on the role of psychosocial factors in the development of hypertension and cardiovascular disease.  These projects focus on a set of inter-related themes concerning the causes and consequences of sustained blood pressure elevation.
Project 1: Masked Hypertension: A Prospective Study of the Development of Hypertension
This study will continue our investigation of MHT through 5-year follow-up exams to assess whether MHT leads to development of essential HT, progression of CV target organ damage (TOD), and increased risk of CV disease (CVD).
Project 2: Psychophysiological Mechanisms in Masked Hypertension
This study will examine physiological and psychological factors associated with delayed post-stress BP recovery, the process we hypothesize contribute to the high daytime BP that is characteristic of MHT. 
Project 3: Improving the Detection of Hypertension: A Diagnostic Research Study
The long-term goal of this study is to improve the detection of HT, including those with MHT, so that treatment decisions are better informed, progression of TOD is slowed, and cardiovascular risk reduced.
 
P01 HL088117 (PI: K. Davidson)                                                     2008-2013           $12,479,004
NIH/NHLBI                                                                
Depression, Biobehavioral Mechanisms, & CHD/Mortality Outcomes     
The goal is to explain the increased prognostic risk in depressed cardiac patients for major adverse cardiac events &/or all cause mortality by dissecting depression into key psychological & biological components & correlates.
 
R01 HL098037 (PI: J.E. Schwartz)                                                  2009-2013             $1,605,975
NIH/NHLBI                                                    
Physical Activity, Depression, and Post-ACS Survival
The goal of this study is to test the hypothesis that physical (in)activity mediates the relationship between depression and cardiac outcome risk.
 
K24 HL084034 (PI: K. Davidson)                                                     2006-2016                $910,075
NIH/NHLBI
Midcareer Mentoring in Behavioral Cardiology: Depression & Cardiovascular Disease
The goals of this study are to determine the point prevalence of underlying medical conditions known to cause depression and excess CHD recurrence/mortality in a large cohort of post-ACS patients and to determine if any of the above medical confounds explains some of the excess risk of depression for CHD recurrence/mortality controlling for standard covariates.
 
K23 HL086734 (PI: T. Goyal-Spruill)                                               2007-2011                $606,561
NIH/NHLBI    
Diagnostic Labeling: Effect on White Coat Hypertension
The goal is to enable Dr. Goyal-Spruill to become an independent scientist with expertise in behavioral and psychological interventions, and to study the effect of diagnostic labeling on white coat hypertension.
 
R01 HL091099 (PI: D. Shimbo)                                                        2008-2011             $1,091,247
NIH/NHLBI                                        
Cardiovascular Disease: Depression and Telomere Length
This study will provide enhanced understanding into how depression increases the risk of incident CVD events.
 
R01 HL084438 (PI: M. Burg)                                                            2007-2012                              
NIH/NHLBI
Reducing Vulnerability To ICD Shock Treated Ventricular Arrhythmias
The long-term objective of this project is to assess the impact on arrhythmia requiring shock for termination among new recipients of an ICD of a stress reduction treatment.
 
R01 HL083056 (PI: L. Clemow)                                                        2007-2012             $3,796,669
NIH/NHLBI                                                                
RCT of Controlled Breathing Effects on Ambulatory BP
The goal is to test the efficacy of a guided breathing intervention on ambulatory blood pressure (ABP) in hypertensives.
 
(PI: T. Pickering, D. Shimbo)                                                           2007-2011       $221,263
CVRx, Inc.                                                     
RHEOS Pivotal Trial
The goal is to demonstrate efficacy and safety of the Rheos system in patients with JNC-7 defined stage II hypertension.
 
(PI: D. Shimbo)                                                                                  2008-2011                $180,000
Irving Clinical Research Career Award    
A Translational Study of Anger, Endothelial Cell Injury, and Oxidative Stress
The purpose of this study is to examine the relation of anger with endothelial cell (EC) injury, a mechanism implicated in atherosclerosis pathogenesis.
 
K23HL098359 (PI: I. Kronish)                                                          2010-2012       $546,361        
Uncontrolled Hypertension: The Role of Clinical Inertia and Medication Adherence
This patient-oriented research award tests the effectiveness of a pilot intervention to improve clinician management of hypertension by electronically monitoring adherence to blood pressure medications and then providing clinicians with quantitative reports summarizing patient adherence. The grant will also assess predictors of uncontrolled hypertension.