Research
Improved Methods of Measurement
- To develop and test novel, field applicable methods of blood pressure measurement
- To develop and test novel depression assessments for patients with coronary heart disease
Stress, Emotion and the Pathophysiology of Cardiovascular Disease
- To identify depression phenotypes who are at increased risk for acute coronary syndromes
- To test behavioral and pathophysiological mechanisms by which these phenotypes might confer risk
- To identify cognitive and emotional underpinnings of sustained blood pressure elevation
- To study the relationship of emotional factors to, and the effect of emotional expression on, sustained blood pressure elevation, endothelial function, immune system activity, myocardial infarction, and arrhythmogenesis.
Treatments
- To develop and test behavioral interventions for depression, anger, and related emotional factors, with the aim of improving cardiac event-free survival
- To develop and test behavioral interventions to increase medication adherence in hypertensive and cardiac patient populations
- To develop and test behavioral interventions to reduce blood pressure
New Methods of Predicting Cardiovascular Risk
- 24-hour ambulatory blood pressure monitoring
- Inflammatory markers
- Pulse wave analysis and pulse wave velocity analysis
- Assessment of endothelial dysfunction
- Gene-environment interactions
- Depression
- Chronic stress
- Anger
- Positive emotions