Research

Improved Methods of Measurement

  • To develop and test novel, field applicable methods of blood pressure measurement
  • To develop and test novel depression assessments for patients with coronary heart disease

Stress, Emotion and the Pathophysiology of Cardiovascular Disease

  • To identify depression phenotypes who are at increased risk for acute coronary syndromes
  • To test behavioral and pathophysiological mechanisms by which these phenotypes might confer risk
  • To identify cognitive and emotional underpinnings of sustained blood pressure elevation
  • To study the relationship of emotional factors to, and the effect of emotional expression on, sustained blood pressure elevation, endothelial function, immune system activity, myocardial infarction, and arrhythmogenesis.

Treatments

  • To develop and test behavioral interventions for depression, anger, and related emotional factors, with the aim of improving cardiac event-free survival
  • To develop and test behavioral interventions to increase medication adherence in hypertensive and cardiac patient populations
  • To develop and test behavioral interventions to reduce blood pressure

New Methods of Predicting Cardiovascular Risk

  • 24-hour ambulatory blood pressure monitoring
  • Inflammatory markers
  • Pulse wave analysis and pulse wave velocity analysis
  • Assessment of endothelial dysfunction
  • Gene-environment interactions
  • Depression
  • Chronic stress
  • Anger
  • Positive emotions