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Nicole Schupf, PhD

  • Professor of Epidemiology (in the Gertrude H. Sergievsky Center, in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and in Psychiatry) at the Columbia University Medical Center
Nicole Schupf, PhD

Dr. Schupf trained originally as a physiological psychologist, receiving her Ph.D. from New York University in 1970. She worked for several years on neuroimmunological mechanisms in lupus cerebritis. She then received her M.P.H. from the University of California in 1984 and a Dr.P.H. in Epidemiology from Columbia University in 1995. She is a Professor of Epidemiology at CUMC in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Faculty of Medicine. Nicole Schupf conducts studies of aging and Alzheimer’s disease in adults with Down syndrome and in the general population.

A major focus of her work has been the investigation of genetic and nongenetic factors that influence risk or age at onset of Alzheimer's disease in individuals with Down syndrome and in a multi-ethnic Northern Manhattan cohort. Current work focuses on a longitudinal and multidisciplinary determination of key biomarkers that are likely to define the progression from normal aging to onset of dementia in adults with Down syndrome, including levels and rates of change in blood-based biomarkers such as beta-amyloid peptides, protein, inflammatory and lipid profiles, measures of amyloid and tau concentration in cerebrospinal fluid, neuroimaging-based changes, PET studies of brain amyloid uptake, and genetic polymorphisms.

Departmental Appointments

  • Department of Epidemiology
  • Department of Psychiatry
    Division of Epidemiology

Research Interests

  • Epidemiology

NIH Grants

  • WHICAP -GENETIC EPIDEMIOLOGY OF CEREBROVASCULAR FACTORS IN ALZHEIMER S DISEASE (Federal Gov)

    Aug 1 2016 - Jun 30 2021

    OFFSPRING STUDY OF MECHANISMS OF RACIAL DISPARITIES IN ALZHEIMER S DISEASE (Federal Gov)

    Sep 1 2016 - Mar 31 2021

    BENFOTIAMINE IN ALZHEIMER S DISEASE: A PILOT STUDY (Federal Gov)

    Sep 1 2014 - May 31 2019

    LONG LIFE FAMILY STUDY: COLUMBIA UNIVERSITY (Federal Gov)

    May 1 2014 - May 31 2019

    PROTEOMIC PROFILE FOR INCIDENT ALZHEIMER S DISEASE (Private)

    Nov 1 2015 - Oct 31 2018

    WHITE MATTER HYPERINTENSITIES IN AGING AND DEMENTIA (Federal Gov)

    Sep 30 2016 - Aug 31 2017

    EPIDEMIOLOGY OF BIOMARKERS OF RISK AND PROGRESSION IN LOAD (Federal Gov)

    May 1 2010 - Apr 30 2017

    RE-VISITING METHODS FOR MCI DIAGNOSIS TO IMPROVE BIOMARKER AND TRIAL FINDINGS (Federal Gov)

    Mar 15 2016 - Feb 28 2017

    BENFOTIAMINE IN ALZHEIMER S DISEASE: A PILOT STUDY (Private)

    Jan 1 2015 - Dec 31 2016

    PERIODONTITIS EXPOSURE AND RISK OF INCIDENT DEMENTIA (Federal Gov)

    Sep 17 2013 - Aug 31 2016

    EPIGENETIC EVENTS UNDERLYING TYPE I DIABETES (Federal Gov)

    Sep 20 2011 - Jun 30 2016

    GENETIC EPIDEMIOLOGY OF ALZHEIMER S DISEASE IN HISPANICS (Federal Gov)

    Feb 1 2009 - Jan 31 2016

    EPIGENOMICS OF ALZHEIMER S DISEASE (Federal Gov)

    Sep 15 2009 - Aug 31 2015

    AGING AND DEMENTIA IN ADULTS WITH DOWN SYNDROME (Federal Gov)

    Jul 1 2010 - May 31 2015

    OFFSPRING OF ETHNICALLY DIVERSE PEOPLE WITH AND WITHOUT ALZHEIMER S DISEASE (Private)

    Apr 1 2012 - Mar 31 2015

    EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME (Federal Gov)

    Apr 1 1998 - Jul 31 2012

    AGING AND DEMENTIA IN ADULTS WITH DOWN SYNDROME (Federal Gov)

    Jul 1 2010 - May 31 2012

    GENETICS OF ESTROGEN AND ALZHEIMER"S DISEASE IN A MULTIETHNI C COHORT (Private)

    Sep 1 2008 - Aug 31 2011

    CHANGE IN THE FUNCTIONING AMONG ADULTS WITH MENTALLY RETARDE D ADULTS (Federal Gov)

    Sep 1 2007 - Aug 31 2010